DegronMD - Q13144(EIF2B5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T162A	TCGA-A5-A0G2	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.1111
p.T162A	DO41235	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.1111
p.R145H	TCGA-AP-A0LM	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.R145H	TCGA-AX-A1CE	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.R145H	DO43306	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.R145H	DO42280	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.R145C	TCGA-AX-A1CE	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.R145C	DO42280	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.I156S	TCGA-EO-A22X	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2778
p.I156S	DO43907	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2778
p.A140S	TCGA-FA-A6HN	DLBC	TCGA	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.0833
p.A140S	DO219887	DLBC	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.0833
p.L149F	TCGA-FS-A4F8	SKCM	TCGA	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation altering degron motif	0.587
p.L149F	DO38117	SKCM	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation altering degron motif	0.587
p.Y152C	DO230347	COCA	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation altering degron motif	0.7087
p.G153W	DO228974	LICA	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation altering degron motif	0.6714
p.V151L	DO229032	LICA	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation altering degron motif	0.5654
p.D147Y	DO229045	LICA	ICGC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2778
p.R145L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.R145L	ACH-000920	Leukemia	CCLE	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222
p.R145L	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LLVYGD	LIG_APCC_ABBA_1	149:154	Mutation rewiring degron network	0.2222

Kaplan plot for EIF2B5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF2B5

UniProt ID: Q13144

Entrez ID: 8893

Protein name: Translation initiation factor eIF-2B subunit epsilon (eIF-2B GDP-GTP exchange factor subunit epsilon)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF2B5 in