DegronMD

Uniprot ID: Q13144

Source protein: Translation initiation factor eIF-2B subunit epsilon

Source gene: EIF2B5

Class: LIG_APCC_ABBA_1

Location: 149:154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7296

ASA_SCORE: 6.7667

COIL: 0.3262

CONS_SCORE: 0.5701

DSS_SCORE: 0.011

HELIX: 0.0095

FCONS_SCORE: 1.3044

RIG_SCORE: 0.9168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T162A	TCGA-A5-A0G2	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	0.1111
p.T162A	DO41235	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.1111
p.R145H	TCGA-AP-A0LM	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.R145H	TCGA-AX-A1CE	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.R145H	DO43306	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.R145H	DO42280	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.R145C	TCGA-AX-A1CE	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.R145C	DO42280	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.I156S	TCGA-EO-A22X	UCEC	TCGA	LLVYGD	LIG_APCC_ABBA_1	0.2778
p.I156S	DO43907	UCEC	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.2778
p.A140S	TCGA-FA-A6HN	DLBC	TCGA	LLVYGD	LIG_APCC_ABBA_1	0.0833
p.A140S	DO219887	DLBC	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.0833
p.L149F	TCGA-FS-A4F8	SKCM	TCGA	LLVYGD	LIG_APCC_ABBA_1	0.587
p.L149F	DO38117	SKCM	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.587
p.Y152C	DO230347	COCA	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.7087
p.G153W	DO228974	LICA	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.6714
p.V151L	DO229032	LICA	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.5654
p.D147Y	DO229045	LICA	ICGC	LLVYGD	LIG_APCC_ABBA_1	0.2778
p.R145L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.R145L	ACH-000920	Leukemia	CCLE	LLVYGD	LIG_APCC_ABBA_1	0.2222
p.R145L	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LLVYGD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13144	Translation initiation factor eIF-2B subunit epsilon	LIG_APCC_ABBA_1	149:154	LLVYGD	APC,CDC20,FZR1	0.7296	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons