DegronMD - Q13155(AIMP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q179R	TCGA-A5-A1OF	UCEC	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.1667
p.Q179E	TCGA-AF-3911	READ	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.1667
p.Y181F	TCGA-DM-A1HB	COAD	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.2222
p.K190N	TCGA-FI-A2EY	UCEC	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.5806
p.A185S	DO229037	LICA	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.7588
p.R188C	DO229050	LICA	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.8301
p.A185T	DO232224	PBCA	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.7139
p.G195V	DO48009	STAD	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.25
p.A201T	DO47811	STAD	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.0833
p.S192F	DO41999	UCEC	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.7982
p.R188L	DO41379	UCEC	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.8428
p.R178H	SIDM01088	Endometrial Carcinoma	GDSC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.1389
p.R178H	RL95-2	endometrium	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.1389
p.V201M	ACH-000938	Leukemia	CCLE	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.0833
p.V201M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.0833
p.G193E	ACH-000981	Leukemia	CCLE	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.3056
p.G193E	DND-41	haematopoietic and lymphoid tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.3056
p.A176T	ACH-001610	Brain Cancer	CCLE	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.0833
p.R188H	SNU-449	liver	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.8244
p.R188H	ME-1	haematopoietic and lymphoid tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.8244
p.R188H	SKG-IIIa	cervix	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation altering degron motif	0.8244
p.R179H	ME-1	haematopoietic and lymphoid tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.1667
p.R179H	SKG-IIIa	cervix	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.1667
p.R179H	SNU-449	liver	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.1667
p.G202E	DND-41	haematopoietic and lymphoid tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	185:192	Mutation rewiring degron network	0.0556

Kaplan plot for AIMP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AIMP2

UniProt ID: Q13155

Entrez ID: 7965

Protein name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (Multisynthase complex auxiliary component p38) (Protein JTV-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AIMP2 in