DegronMD

Uniprot ID: Q13155

Source protein: Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

Source gene: AIMP2

Class: DEG_MDM2_SWIB_1

Location: 185:192

E3 ligase: MDM2

DEGRON score: 0.6278

ASA_SCORE: 30.8375

COIL: 0.2019

CONS_SCORE: 0.6816

DSS_SCORE: 0.2153

HELIX: 0.0118

FCONS_SCORE: 1.5906

RIG_SCORE: 0.8993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q179R	TCGA-A5-A1OF	UCEC	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	0.1667
p.Q179E	TCGA-AF-3911	READ	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	0.1667
p.Y181F	TCGA-DM-A1HB	COAD	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	0.2222
p.K190N	TCGA-FI-A2EY	UCEC	TCGA	FTLIWKNV	DEG_MDM2_SWIB_1	0.5806
p.A185S	DO229037	LICA	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	0.7588
p.R188C	DO229050	LICA	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	0.8301
p.A185T	DO232224	PBCA	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	0.7139
p.G195V	DO48009	STAD	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	0.25
p.A201T	DO47811	STAD	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	0.0833
p.S192F	DO41999	UCEC	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	0.7982
p.R188L	DO41379	UCEC	ICGC	FTLIWKNV	DEG_MDM2_SWIB_1	0.8428
p.R178H	SIDM01088	Endometrial Carcinoma	GDSC	FTLIWKNV	DEG_MDM2_SWIB_1	0.1389
p.R178H	RL95-2	endometrium	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.1389
p.V201M	ACH-000938	Leukemia	CCLE	FTLIWKNV	DEG_MDM2_SWIB_1	0.0833
p.V201M	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.0833
p.G193E	ACH-000981	Leukemia	CCLE	FTLIWKNV	DEG_MDM2_SWIB_1	0.3056
p.G193E	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.3056
p.A176T	ACH-001610	Brain Cancer	CCLE	FTLIWKNV	DEG_MDM2_SWIB_1	0.0833
p.R188H	SNU-449	liver	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.8244
p.R188H	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.8244
p.R188H	SKG-IIIa	cervix	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.8244
p.R179H	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.1667
p.R179H	SKG-IIIa	cervix	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.1667
p.R179H	SNU-449	liver	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.1667
p.G202E	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	FTLIWKNV	DEG_MDM2_SWIB_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13155	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	DEG_MDM2_SWIB_1	185:192	FTLIWKNV	MDM2	0.6278	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FTLIWKNV

Degron related mutations and impact score

Drug responses associated with AIMP2 mutations

All proteins holding degron of FTLIWKNV