DegronMD - Q13201(MMRN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P40S	TCGA-2V-A95S	LIHC	TCGA	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6752
p.P40S	TCGA-ND-A4WC	UCS	TCGA	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6752
p.P40S	DO223911	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6752
p.P30L	TCGA-AG-3592	READ	TCGA	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.0833
p.P30L	DO37308	READ	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.0833
p.P45T	TCGA-BW-A5NP	LIHC	TCGA	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.5919
p.P45T	DO52172	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.5919
p.P45H	TCGA-BW-A5NP	LIHC	TCGA	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6583
p.P45H	DO52172	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6583
p.M39V	TCGA-EW-A1IZ	BRCA	TCGA	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6097
p.M39V	DO2937	BRCA	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6097
p.P45R	TCGA-F5-6814	READ	TCGA	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6401
p.P45R	DO36556	READ	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6401
p.A49P	DO219024	BLCA	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.2778
p.P46S	DO218173	BRCA	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.6752
p.T35I	DO3686	BRCA	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.2222
p.I49T	DO233649	GACA	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.2778
p.A49V	DO13863	GBM	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.2778
p.C57F	DO52170	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.0556
p.Q50R	DO45181	LIRI	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.25
p.Q37H	DO23846	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.2778
p.A38S	DO23846	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation blocking phosphorylation signal	0.75
p.G45C	DO45319	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.76
p.G47V	DO24900	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.7532
p.Q51H	DO228564	MALY	ICGC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.2222
p.E31K	SIDM02055	Colorectal Carcinoma	GDSC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation rewiring degron network	0.1111
p.V44I	SIDM00694	Other Solid Cancers	GDSC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.7076
p.V44I	SIDM00068	Colorectal Carcinoma	GDSC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.7076
p.V44I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.7076
p.T42K	ACH-000875	Lung Cancer	CCLE	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.7306
p.T42K	NCI-H2347	lung	COSMIC	MPSASVPPN	DEG_SIAH_1	39:47	Mutation altering degron motif	0.7306

Kaplan plot for MMRN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMRN1

UniProt ID: Q13201

Entrez ID: 22915

Protein name: Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMRN1 in