DegronMD

Uniprot ID: Q13201

Source protein: Multimerin-1

Source gene: MMRN1

Class: DEG_SIAH_1

Location: 39:47

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9983

ASA_SCORE: 66.1556

COIL: 0.8439

CONS_SCORE: 0.5244

DSS_SCORE: 0.6369

HELIX: 0.068

FCONS_SCORE: 0.995

RIG_SCORE: 0.6603

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P40S	TCGA-2V-A95S	LIHC	TCGA	MPSASVPPN	DEG_SIAH_1	0.6752
p.P40S	TCGA-ND-A4WC	UCS	TCGA	MPSASVPPN	DEG_SIAH_1	0.6752
p.P40S	DO223911	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	0.6752
p.P30L	TCGA-AG-3592	READ	TCGA	MPSASVPPN	DEG_SIAH_1	0.0833
p.P30L	DO37308	READ	ICGC	MPSASVPPN	DEG_SIAH_1	0.0833
p.P45T	TCGA-BW-A5NP	LIHC	TCGA	MPSASVPPN	DEG_SIAH_1	0.5919
p.P45T	DO52172	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	0.5919
p.P45H	TCGA-BW-A5NP	LIHC	TCGA	MPSASVPPN	DEG_SIAH_1	0.6583
p.P45H	DO52172	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	0.6583
p.M39V	TCGA-EW-A1IZ	BRCA	TCGA	MPSASVPPN	DEG_SIAH_1	0.6097
p.M39V	DO2937	BRCA	ICGC	MPSASVPPN	DEG_SIAH_1	0.6097
p.P45R	TCGA-F5-6814	READ	TCGA	MPSASVPPN	DEG_SIAH_1	0.6401
p.P45R	DO36556	READ	ICGC	MPSASVPPN	DEG_SIAH_1	0.6401
p.A49P	DO219024	BLCA	ICGC	MPSASVPPN	DEG_SIAH_1	0.2778
p.P46S	DO218173	BRCA	ICGC	MPSASVPPN	DEG_SIAH_1	0.6752
p.T35I	DO3686	BRCA	ICGC	MPSASVPPN	DEG_SIAH_1	0.2222
p.I49T	DO233649	GACA	ICGC	MPSASVPPN	DEG_SIAH_1	0.2778
p.A49V	DO13863	GBM	ICGC	MPSASVPPN	DEG_SIAH_1	0.2778
p.C57F	DO52170	LIHC	ICGC	MPSASVPPN	DEG_SIAH_1	0.0556
p.Q50R	DO45181	LIRI	ICGC	MPSASVPPN	DEG_SIAH_1	0.25
p.Q37H	DO23846	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	0.2778
p.A38S	DO23846	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	0.75
p.G45C	DO45319	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	0.76
p.G47V	DO24900	LUAD	ICGC	MPSASVPPN	DEG_SIAH_1	0.7532
p.Q51H	DO228564	MALY	ICGC	MPSASVPPN	DEG_SIAH_1	0.2222
p.E31K	SIDM02055	Colorectal Carcinoma	GDSC	MPSASVPPN	DEG_SIAH_1	0.1111
p.V44I	SIDM00694	Other Solid Cancers	GDSC	MPSASVPPN	DEG_SIAH_1	0.7076
p.V44I	SIDM00068	Colorectal Carcinoma	GDSC	MPSASVPPN	DEG_SIAH_1	0.7076
p.V44I	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	MPSASVPPN	DEG_SIAH_1	0.7076
p.T42K	ACH-000875	Lung Cancer	CCLE	MPSASVPPN	DEG_SIAH_1	0.7306
p.T42K	NCI-H2347	lung	COSMIC	MPSASVPPN	DEG_SIAH_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13201	Multimerin-1	DEG_SIAH_1	39:47	MPSASVPPN	SIAH1,SIAH2,SIAH3	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MPSASVPPN

Degron related mutations and impact score

Drug responses associated with MMRN1 mutations

All proteins holding degron of MPSASVPPN