DegronMD - Q13203(MYBPH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A73D	TCGA-21-1071	LUSC	TCGA	VSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.A73D	DO26918	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.G9V	TCGA-49-AAR9	LUAD	TCGA	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1667
p.G9V	DO218921	LUAD	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1667
p.G9C	TCGA-AJ-A3IA	UCEC	TCGA	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1667
p.G9C	DO43082	UCEC	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1667
p.P30S	TCGA-B6-A1KF	BRCA	TCGA	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.25
p.P30S	DO1604	BRCA	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.25
p.L77P	TCGA-BR-8080	STAD	TCGA	VSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.L77P	DO38651	STAD	ICGC	VSSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.E16D	TCGA-FI-A2D5	UCEC	TCGA	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation altering degron motif	0.5647
p.E16D	DO41331	UCEC	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation altering degron motif	0.5647
p.P10L	TCGA-FW-A3R5	SKCM	TCGA	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1944
p.P10L	DO37406	SKCM	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1944
p.P10S	TCGA-ZS-A9CE	LIHC	TCGA	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1944
p.P10S	DO49720	LIHC	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1944
p.P29T	DO229015	LICA	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.2778
p.V33M	DO220903	MELA	ICGC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1667
p.E8K	SIDM00078	Oral Cavity Carcinoma	GDSC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1389
p.E8K	BICR31	upper aerodigestive tract	COSMIC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1389
p.E32V	SIDM00699	Small Cell Lung Carcinoma	GDSC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1944
p.E32V	NCI-H2141	lung	COSMIC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.1944
p.S21P	SIDM01451	Pancreatic Carcinoma	GDSC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation altering degron motif	0.5641
p.S21P	ACH-000933	Pancreatic Cancer	CCLE	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation altering degron motif	0.5641
p.C12S	MDA-MB-468	breast	COSMIC	EETASESAKVPTA	DEG_COP1_1	15:27	Mutation rewiring degron network	0.25

Kaplan plot for MYBPH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBPH

UniProt ID: Q13203

Entrez ID: 4608

Protein name: Myosin-binding protein H (MyBP-H) (H-protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYBPH in