DegronMD

Uniprot ID: Q13203

Source protein: Myosin-binding protein H

Source gene: MYBPH

Class: DEG_COP1_1

Location: 15:27

E3 ligase: COP1

DEGRON score: 0.8689

ASA_SCORE: 71.3385

COIL: 0.4874

CONS_SCORE: 0.5305

DSS_SCORE: 0.7286

HELIX: 0.0548

FCONS_SCORE: 0.9864

RIG_SCORE: 0.6035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G9V	TCGA-49-AAR9	LUAD	TCGA	EETASESAKVPTA	DEG_COP1_1	0.1667
p.G9V	DO218921	LUAD	ICGC	EETASESAKVPTA	DEG_COP1_1	0.1667
p.G9C	TCGA-AJ-A3IA	UCEC	TCGA	EETASESAKVPTA	DEG_COP1_1	0.1667
p.G9C	DO43082	UCEC	ICGC	EETASESAKVPTA	DEG_COP1_1	0.1667
p.P30S	TCGA-B6-A1KF	BRCA	TCGA	EETASESAKVPTA	DEG_COP1_1	0.25
p.P30S	DO1604	BRCA	ICGC	EETASESAKVPTA	DEG_COP1_1	0.25
p.E16D	TCGA-FI-A2D5	UCEC	TCGA	EETASESAKVPTA	DEG_COP1_1	0.5647
p.E16D	DO41331	UCEC	ICGC	EETASESAKVPTA	DEG_COP1_1	0.5647
p.P10L	TCGA-FW-A3R5	SKCM	TCGA	EETASESAKVPTA	DEG_COP1_1	0.1944
p.P10L	DO37406	SKCM	ICGC	EETASESAKVPTA	DEG_COP1_1	0.1944
p.P10S	TCGA-ZS-A9CE	LIHC	TCGA	EETASESAKVPTA	DEG_COP1_1	0.1944
p.P10S	DO49720	LIHC	ICGC	EETASESAKVPTA	DEG_COP1_1	0.1944
p.P29T	DO229015	LICA	ICGC	EETASESAKVPTA	DEG_COP1_1	0.2778
p.V33M	DO220903	MELA	ICGC	EETASESAKVPTA	DEG_COP1_1	0.1667
p.E8K	SIDM00078	Oral Cavity Carcinoma	GDSC	EETASESAKVPTA	DEG_COP1_1	0.1389
p.E8K	BICR31	upper_aerodigestive_tract	COSMIC	EETASESAKVPTA	DEG_COP1_1	0.1389
p.E32V	SIDM00699	Small Cell Lung Carcinoma	GDSC	EETASESAKVPTA	DEG_COP1_1	0.1944
p.E32V	NCI-H2141	lung	COSMIC	EETASESAKVPTA	DEG_COP1_1	0.1944
p.S21P	SIDM01451	Pancreatic Carcinoma	GDSC	EETASESAKVPTA	DEG_COP1_1	0.5641
p.S21P	ACH-000933	Pancreatic Cancer	CCLE	EETASESAKVPTA	DEG_COP1_1	0.5641
p.C12S	MDA-MB-468	breast	COSMIC	EETASESAKVPTA	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13203	Myosin-binding protein H	DEG_COP1_1	15:27	EETASESAKVPTA	COP1	0.8689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons