DegronMD - Q13231(CHIT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G393D	TCGA-44-A47F	LUAD	TCGA	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation altering degron motif	0.6087
p.G393D	DO24180	LUAD	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation altering degron motif	0.6087
p.E398Q	TCGA-AR-A2LE	BRCA	TCGA	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation altering degron motif	0.6744
p.E398Q	DO1932	BRCA	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation altering degron motif	0.6744
p.R382W	TCGA-B5-A11E	UCEC	TCGA	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.0833
p.R382W	DO41644	UCEC	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.0833
p.K401N	TCGA-BR-6452	STAD	TCGA	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation substituting flanking lysine	0.3611
p.K401N	DO38404	STAD	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation substituting flanking lysine	0.3611
p.L387I	TCGA-EO-A3B0	UCEC	TCGA	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.2222
p.L387I	DO219773	UCEC	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.2222
p.L397F	TCGA-MP-A4TC	LUAD	TCGA	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation altering degron motif	0.587
p.L397F	DO45342	LUAD	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation altering degron motif	0.587
p.G393S	DO233871	GACA	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation altering degron motif	0.5882
p.P408S	DO229256	LMS	ICGC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.0556
p.P408L	SIDM01229	Neuroblastoma	GDSC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.0556
p.P408L	ACH-000312	Neuroblastoma	CCLE	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.0556
p.P408L	ACH-002217	Neuroblastoma	CCLE	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.0556
p.P408L	BE2-M17	autonomic ganglia	COSMIC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.0556
p.P389L	BE2-M17	autonomic ganglia	COSMIC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.2778
p.F400L	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PSGTPELE	DEG_SCF_FBW7_2	391:398	Mutation rewiring degron network	0.2778

Kaplan plot for CHIT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHIT1

UniProt ID: Q13231

Entrez ID: 1118

Protein name: Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHIT1 in