DegronMD

Uniprot ID: Q13231

Source protein: Chitotriosidase-1

Source gene: CHIT1

Class: DEG_SCF_FBW7_2

Location: 391:398

E3 ligase: FBXW7

DEGRON score: 0.9792

ASA_SCORE: 75.7875

COIL: 0.856

CONS_SCORE: 0.7368

DSS_SCORE: 0.6464

HELIX: 0.0275

FCONS_SCORE: 0.9978

RIG_SCORE: 0.6159

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G393D	TCGA-44-A47F	LUAD	TCGA	PSGTPELE	DEG_SCF_FBW7_2	0.6087
p.G393D	DO24180	LUAD	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.6087
p.E398Q	TCGA-AR-A2LE	BRCA	TCGA	PSGTPELE	DEG_SCF_FBW7_2	0.6744
p.E398Q	DO1932	BRCA	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.6744
p.R382W	TCGA-B5-A11E	UCEC	TCGA	PSGTPELE	DEG_SCF_FBW7_2	0.0833
p.R382W	DO41644	UCEC	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.0833
p.K401N	TCGA-BR-6452	STAD	TCGA	PSGTPELE	DEG_SCF_FBW7_2	0.3611
p.K401N	DO38404	STAD	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.3611
p.L387I	TCGA-EO-A3B0	UCEC	TCGA	PSGTPELE	DEG_SCF_FBW7_2	0.2222
p.L387I	DO219773	UCEC	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.2222
p.L397F	TCGA-MP-A4TC	LUAD	TCGA	PSGTPELE	DEG_SCF_FBW7_2	0.587
p.L397F	DO45342	LUAD	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.587
p.G393S	DO233871	GACA	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.5882
p.P408S	DO229256	LMS	ICGC	PSGTPELE	DEG_SCF_FBW7_2	0.0556
p.P408L	SIDM01229	Neuroblastoma	GDSC	PSGTPELE	DEG_SCF_FBW7_2	0.0556
p.P408L	ACH-000312	Neuroblastoma	CCLE	PSGTPELE	DEG_SCF_FBW7_2	0.0556
p.P408L	ACH-002217	Neuroblastoma	CCLE	PSGTPELE	DEG_SCF_FBW7_2	0.0556
p.P408L	BE2-M17	autonomic_ganglia	COSMIC	PSGTPELE	DEG_SCF_FBW7_2	0.0556
p.P389L	BE2-M17	autonomic_ganglia	COSMIC	PSGTPELE	DEG_SCF_FBW7_2	0.2778
p.F400L	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPELE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13231	Chitotriosidase-1	DEG_SCF_FBW7_2	391:398	PSGTPELE	FBXW7	0.9792	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons