DegronMD - Q13239(SLA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S163L	TCGA-06-5416	GBM	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.1389
p.P186L	TCGA-A5-A0G2	UCEC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.0833
p.P186L	SIDM00175	Melanoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.0833
p.P186L	CP50-MEL-B	skin	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.0833
p.R173H	TCGA-AA-3949	COAD	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8244
p.R173H	TCGA-AX-A0J1	UCEC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8244
p.R173H	SIDM00217	Colorectal Carcinoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8244
p.R173H	SNU-1040	large intestine	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8244
p.W181L	TCGA-F7-7848	HNSC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.2222
p.V164A	TCGA-FF-A7CR	DLBC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.1667
p.R176C	TCGA-FS-A1ZZ	SKCM	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8301
p.R176C	SIDM01283	Esophageal Carcinoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8301
p.E171Q	DO590	BLCA	ICGC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.6744
p.D172N	DO220903	MELA	ICGC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.6932
p.P163L	DO41235	UCEC	ICGC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.1389
p.P163L	CP50-MEL-B	skin	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.1389
p.Y182H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.1944
p.Y182H	DND-41	haematopoietic and lymphoid tissue	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation rewiring degron network	0.1944
p.R173C	SIDM01199	Hepatocellular Carcinoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8301
p.R173C	SNU-423	liver	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	170:177	Mutation altering degron motif	0.8301

Kaplan plot for SLA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLA

UniProt ID: Q13239

Entrez ID: 6503

Protein name: Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLA in