DegronMD

Uniprot ID: Q13239

Source protein: Src-like-adapter

Source gene: SLA

Class: DEG_SCF_FBW7_1

Location: 170:177

E3 ligase: FBXW7

DEGRON score: 0.776

ASA_SCORE: 53.5375

COIL: 0.691

CONS_SCORE: 0.8681

DSS_SCORE: 0.0421

HELIX: 0.0375

FCONS_SCORE: 1.3058

RIG_SCORE: 0.8832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S163L	TCGA-06-5416	GBM	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	0.1389
p.P186L	TCGA-A5-A0G2	UCEC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	0.0833
p.P186L	SIDM00175	Melanoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	0.0833
p.P186L	CP50-MEL-B	skin	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	0.0833
p.R173H	TCGA-AA-3949	COAD	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	0.8244
p.R173H	TCGA-AX-A0J1	UCEC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	0.8244
p.R173H	SIDM00217	Colorectal Carcinoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	0.8244
p.R173H	SNU-1040	large_intestine	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	0.8244
p.W181L	TCGA-F7-7848	HNSC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	0.2222
p.V164A	TCGA-FF-A7CR	DLBC	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	0.1667
p.R176C	TCGA-FS-A1ZZ	SKCM	TCGA	VLTTPCLT	DEG_SCF_FBW7_1	0.8301
p.R176C	SIDM01283	Esophageal Carcinoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	0.8301
p.E171Q	DO590	BLCA	ICGC	VLTTPCLT	DEG_SCF_FBW7_1	0.6744
p.D172N	DO220903	MELA	ICGC	VLTTPCLT	DEG_SCF_FBW7_1	0.6932
p.P163L	DO41235	UCEC	ICGC	VLTTPCLT	DEG_SCF_FBW7_1	0.1389
p.P163L	CP50-MEL-B	skin	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	0.1389
p.Y182H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	0.1944
p.Y182H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	0.1944
p.R173C	SIDM01199	Hepatocellular Carcinoma	GDSC	VLTTPCLT	DEG_SCF_FBW7_1	0.8301
p.R173C	SNU-423	liver	COSMIC	VLTTPCLT	DEG_SCF_FBW7_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13239	Src-like-adapter	DEG_SCF_FBW7_1	170:177	VLTTPCLT	FBXW7	0.776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons