DegronMD - Q13242(SRSF9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E174K	DO223015	ESCA	ICGC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.1667
p.P184T	DO229038	LICA	ICGC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation altering degron motif	0.5919
p.S189I	DO229257	THCA	ICGC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation blocking phosphorylation signal	0.6667
p.T177N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.25
p.T177N	ACH-002256	Leukemia	CCLE	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.25
p.T177N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.25
p.T188S	SIDM00814	Other Solid Cancers	GDSC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation blocking phosphorylation signal	0.6944
p.T188S	ACH-001401	Adrenal Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation blocking phosphorylation signal	0.6944
p.T188S	SW13	adrenal gland	COSMIC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation blocking phosphorylation signal	0.6944
p.E176K	SIDM00999	Bladder Carcinoma	GDSC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.2222
p.E176K	ACH-000973	Bladder Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.2222
p.E176K	639-V	urinary tract	COSMIC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.2222
p.T177I	SIDM00867	Glioblastoma	GDSC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.25
p.T177I	ACH-000863	Brain Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.25
p.T177I	DBTRG-05MG	central nervous system	COSMIC	IRVYPE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.25

Kaplan plot for SRSF9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRSF9

UniProt ID: Q13242

Entrez ID: 8683

Protein name: Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRSF9 in