DegronMD

Uniprot ID: Q13242

Source protein: Serine/arginine-rich splicing factor 9

Source gene: SRSF9

Class: LIG_APCC_ABBA_1

Location: 180:185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9776

ASA_SCORE: 79.3833

COIL: 0.5658

CONS_SCORE: 0.4937

DSS_SCORE: 0.4544

HELIX: 0.0243

FCONS_SCORE: 0.9999

RIG_SCORE: 0.7902

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E174K	DO223015	ESCA	ICGC	IRVYPE	LIG_APCC_ABBA_1	0.1667
p.P184T	DO229038	LICA	ICGC	IRVYPE	LIG_APCC_ABBA_1	0.5919
p.S189I	DO229257	THCA	ICGC	IRVYPE	LIG_APCC_ABBA_1	0.6667
p.T177N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	IRVYPE	LIG_APCC_ABBA_1	0.25
p.T177N	ACH-002256	Leukemia	CCLE	IRVYPE	LIG_APCC_ABBA_1	0.25
p.T177N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	IRVYPE	LIG_APCC_ABBA_1	0.25
p.T188S	SIDM00814	Other Solid Cancers	GDSC	IRVYPE	LIG_APCC_ABBA_1	0.6944
p.T188S	ACH-001401	Adrenal Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	0.6944
p.T188S	SW13	adrenal_gland	COSMIC	IRVYPE	LIG_APCC_ABBA_1	0.6944
p.E176K	SIDM00999	Bladder Carcinoma	GDSC	IRVYPE	LIG_APCC_ABBA_1	0.2222
p.E176K	ACH-000973	Bladder Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	0.2222
p.E176K	639-V	urinary_tract	COSMIC	IRVYPE	LIG_APCC_ABBA_1	0.2222
p.T177I	SIDM00867	Glioblastoma	GDSC	IRVYPE	LIG_APCC_ABBA_1	0.25
p.T177I	ACH-000863	Brain Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	0.25
p.T177I	DBTRG-05MG	central_nervous_system	COSMIC	IRVYPE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13242	Serine/arginine-rich splicing factor 9	LIG_APCC_ABBA_1	180:185	IRVYPE	APC,CDC20,FZR1	0.9776	More...
Q6MZW2	Follistatin-related protein 4	LIG_APCC_ABBA_1	343:348	IRVYPE	APC,CDC20,FZR1	0.7179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons