DegronMD - Q6MZW2(FSTL4)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V450M	TCGA-85-6560	LUSC	TCGA	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2222
p.V450M	DO48228	ESCA	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2222
p.V450M	DO26752	LUSC	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2222
p.V464I	TCGA-AY-6197	COAD	TCGA	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1944
p.V464I	DO9956	COAD	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1944
p.V464I	SIDM00454	Rhabdomyosarcoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1944
p.E446K	TCGA-BG-A222	UCEC	TCGA	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1111
p.E446K	DO42977	UCEC	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1111
p.R444L	TCGA-EE-A2ME	SKCM	TCGA	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.R444L	TCGA-GN-A262	SKCM	TCGA	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.R444L	DO37515	SKCM	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.R444L	DO38011	SKCM	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.S449R	TCGA-G7-A8LD	KIRP	TCGA	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation blocking phosphorylation signal	0.6389
p.S449R	DO49761	KIRP	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation blocking phosphorylation signal	0.6389
p.S449R	DO229031	LICA	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation blocking phosphorylation signal	0.6389
p.S449R	DO229041	LICA	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation blocking phosphorylation signal	0.6389
p.P347Q	DO229036	LICA	ICGC	IRVYPE	LIG_APCC_ABBA_1	343:348	Mutation altering degron motif	0.5924
p.V464F	DO229221	THCA	ICGC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1944
p.R344H	SIDM01048	Plasma Cell Myeloma	GDSC	IRVYPE	LIG_APCC_ABBA_1	343:348	Mutation altering degron motif	0.7133
p.R344H	EJM	haematopoietic and lymphoid tissue	COSMIC	IRVYPE	LIG_APCC_ABBA_1	343:348	Mutation altering degron motif	0.7133
p.D459N	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00654	Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00286	Neuroblastoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM01039	Other Solid Cancers	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00522	Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00971	Breast Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00254	Neuroblastoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00097	Breast Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM01159	Other Sarcomas	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00864	Cervical Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM00225	Melanoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.D459N	SIDM01502	Endometrial Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6932
p.E445K	SIDM00213	Thyroid Gland Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.E445K	SIDM00228	Thyroid Gland Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.E445K	ACH-000249	Colon/Colorectal Cancer	CCLE	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.E445K	ACH-000897	Thyroid Cancer	CCLE	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.E445K	ACH-000903	Thyroid Cancer	CCLE	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.E445K	FTC-133	thyroid	COSMIC	FYVFSD	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.Q352P	ACH-001624	Brain Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.2222
p.N339I	KYSE-70	oesophagus	COSMIC	IRVYPE	LIG_APCC_ABBA_1	343:348	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FSTL4

UniProt ID: Q6MZW2

Entrez ID: 23105

Protein name: Follistatin-related protein 4 (Follistatin-like protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FSTL4 in