DegronMD

Uniprot ID: Q6MZW2

Source protein: Follistatin-related protein 4

Source gene: FSTL4

Class: LIG_APCC_ABBA_1

Location: 454:459

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8794

ASA_SCORE: 50.5833

COIL: 0.3267

CONS_SCORE: 0.7033

DSS_SCORE: 0.0334

HELIX: 0.0185

FCONS_SCORE: 1.4647

RIG_SCORE: 0.8905

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V450M	TCGA-85-6560	LUSC	TCGA	FYVFSD	LIG_APCC_ABBA_1	0.2222
p.V450M	DO48228	ESCA	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.2222
p.V450M	DO26752	LUSC	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.2222
p.V464I	TCGA-AY-6197	COAD	TCGA	FYVFSD	LIG_APCC_ABBA_1	0.1944
p.V464I	DO9956	COAD	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.1944
p.V464I	SIDM00454	Rhabdomyosarcoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.1944
p.E446K	TCGA-BG-A222	UCEC	TCGA	FYVFSD	LIG_APCC_ABBA_1	0.1111
p.E446K	DO42977	UCEC	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.1111
p.R444L	TCGA-EE-A2ME	SKCM	TCGA	FYVFSD	LIG_APCC_ABBA_1	0.0556
p.R444L	TCGA-GN-A262	SKCM	TCGA	FYVFSD	LIG_APCC_ABBA_1	0.0556
p.R444L	DO37515	SKCM	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.0556
p.R444L	DO38011	SKCM	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.0556
p.S449R	TCGA-G7-A8LD	KIRP	TCGA	FYVFSD	LIG_APCC_ABBA_1	0.6389
p.S449R	DO49761	KIRP	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.6389
p.S449R	DO229031	LICA	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.6389
p.S449R	DO229041	LICA	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.6389
p.V464F	DO229221	THCA	ICGC	FYVFSD	LIG_APCC_ABBA_1	0.1944
p.D459N	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00654	Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00286	Neuroblastoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM01039	Other Solid Cancers	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00522	Small Cell Lung Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00971	Breast Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00254	Neuroblastoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00097	Breast Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM01159	Other Sarcomas	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00864	Cervical Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM00225	Melanoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.D459N	SIDM01502	Endometrial Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.6932
p.E445K	SIDM00213	Thyroid Gland Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.0833
p.E445K	SIDM00228	Thyroid Gland Carcinoma	GDSC	FYVFSD	LIG_APCC_ABBA_1	0.0833
p.E445K	ACH-000249	Colon/Colorectal Cancer	CCLE	FYVFSD	LIG_APCC_ABBA_1	0.0833
p.E445K	ACH-000897	Thyroid Cancer	CCLE	FYVFSD	LIG_APCC_ABBA_1	0.0833
p.E445K	ACH-000903	Thyroid Cancer	CCLE	FYVFSD	LIG_APCC_ABBA_1	0.0833
p.E445K	FTC-133	thyroid	COSMIC	FYVFSD	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FYVFSD

Degron related mutations and impact score

Drug responses associated with FSTL4 mutations

All proteins holding degron of FYVFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6MZW2	Follistatin-related protein 4	LIG_APCC_ABBA_1	454:459	FYVFSD	APC,CDC20,FZR1	0.8794	More...