DegronMD

Uniprot ID: Q6MZW2

Source protein: Follistatin-related protein 4

Source gene: FSTL4

Class: LIG_APCC_ABBA_1

Location: 343:348

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7179

ASA_SCORE: 77.3667

COIL: 0.5282

CONS_SCORE: 0.5799

DSS_SCORE: 0.3587

HELIX: 0.0035

FCONS_SCORE: 1.0973

RIG_SCORE: 0.8138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P347Q	DO229036	LICA	ICGC	IRVYPE	LIG_APCC_ABBA_1	0.5924
p.R344H	SIDM01048	Plasma Cell Myeloma	GDSC	IRVYPE	LIG_APCC_ABBA_1	0.7133
p.R344H	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	IRVYPE	LIG_APCC_ABBA_1	0.7133
p.Q352P	ACH-001624	Brain Cancer	CCLE	IRVYPE	LIG_APCC_ABBA_1	0.2222
p.N339I	KYSE-70	oesophagus	COSMIC	IRVYPE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13242	Serine/arginine-rich splicing factor 9	LIG_APCC_ABBA_1	180:185	IRVYPE	APC,CDC20,FZR1	0.9776	More...
Q6MZW2	Follistatin-related protein 4	LIG_APCC_ABBA_1	343:348	IRVYPE	APC,CDC20,FZR1	0.7179	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons