DegronMD - Q13247(SRSF6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K290N	TCGA-06-0125	GBM	TCGA	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation substituting flanking lysine	0.3056
p.K290N	DO13510	GBM	ICGC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation substituting flanking lysine	0.3056
p.R273Q	TCGA-AG-3592	READ	TCGA	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	TCGA-L5-A4OO	ESCA	TCGA	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	DO52365	LUSC	ICGC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	DO37308	READ	ICGC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00568	Gastric Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01093	Cervical Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00556	Neuroblastoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01653	Non-Cancerous	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00397	Acute Myeloid Leukemia	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00207	Glioblastoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00986	Head and Neck Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00575	Glioma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01659	Kidney Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01449	Pancreatic Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01617	Endometrial Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01368	Gastric Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01432	Kidney Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM00784	Glioma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.R273Q	SIDM01434	Hepatocellular Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1111
p.S291P	TCGA-AX-A06F	UCEC	TCGA	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation blocking phosphorylation signal	0.6111
p.S291P	DO41752	UCEC	ICGC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation blocking phosphorylation signal	0.6111
p.S272F	DO220898	MELA	ICGC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation blocking phosphorylation signal	0.5278
p.K271R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation substituting flanking lysine	0.1667
p.K271R	ACH-000920	Leukemia	CCLE	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation substituting flanking lysine	0.1667
p.S276A	SIDM00500	Colorectal Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1944
p.S276A	ACH-000959	Colon/Colorectal Cancer	CCLE	PKENG	DEG_APCC_KENBOX_2	281:285	Mutation rewiring degron network	0.1944

Kaplan plot for SRSF6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRSF6

UniProt ID: Q13247

Entrez ID: 6431

Protein name: Serine/arginine-rich splicing factor 6 (Pre-mRNA-splicing factor SRP55) (Splicing factor, arginine/serine-rich 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SRSF6 in