DegronMD

Uniprot ID: Q13247

Source protein: Serine/arginine-rich splicing factor 6

Source gene: SRSF6

Class: DEG_APCC_KENBOX_2

Location: 281:285

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 106.86

COIL: 0.9144

CONS_SCORE: 0.4349

DSS_SCORE: 0.8108

HELIX: 0.0686

FCONS_SCORE: 1.2241

RIG_SCORE: 0.4903

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K290N	TCGA-06-0125	GBM	TCGA	PKENG	DEG_APCC_KENBOX_2	0.3056
p.K290N	DO13510	GBM	ICGC	PKENG	DEG_APCC_KENBOX_2	0.3056
p.R273Q	TCGA-AG-3592	READ	TCGA	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	TCGA-L5-A4OO	ESCA	TCGA	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	DO52365	LUSC	ICGC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	DO37308	READ	ICGC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00568	Gastric Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01093	Cervical Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00556	Neuroblastoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01653	Non-Cancerous	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00397	Acute Myeloid Leukemia	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00207	Glioblastoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00986	Head and Neck Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00575	Glioma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01659	Kidney Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01449	Pancreatic Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01617	Endometrial Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01368	Gastric Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01432	Kidney Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM00784	Glioma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.R273Q	SIDM01434	Hepatocellular Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1111
p.S291P	TCGA-AX-A06F	UCEC	TCGA	PKENG	DEG_APCC_KENBOX_2	0.6111
p.S291P	DO41752	UCEC	ICGC	PKENG	DEG_APCC_KENBOX_2	0.6111
p.S272F	DO220898	MELA	ICGC	PKENG	DEG_APCC_KENBOX_2	0.5278
p.K271R	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1667
p.K271R	ACH-000920	Leukemia	CCLE	PKENG	DEG_APCC_KENBOX_2	0.1667
p.S276A	SIDM00500	Colorectal Carcinoma	GDSC	PKENG	DEG_APCC_KENBOX_2	0.1944
p.S276A	ACH-000959	Colon/Colorectal Cancer	CCLE	PKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13247	Serine/arginine-rich splicing factor 6	DEG_APCC_KENBOX_2	281:285	PKENG	APC,CDC20,FZR1	0.9967	More...
Q8N4B1	Sesquipedalian-1	DEG_APCC_KENBOX_2	183:187	PKENG	APC,CDC20,FZR1	0.9238	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENG

Degron related mutations and impact score

Drug responses associated with SRSF6 mutations

All proteins holding degron of PKENG