DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PKENG
Uniprot ID:
Q8N4B1
Source protein:
Sesquipedalian-1
Source gene:
PHETA1
Class:
DEG_APCC_KENBOX_2
Location:
183:187
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9238
ASA_SCORE:
102.36
COIL:
0.8718
CONS_SCORE:
0.4045
DSS_SCORE:
0.5617
HELIX:
0.0912
FCONS_SCORE:
1.0104
RIG_SCORE:
0.5904
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PHETA1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PKENG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13247
Serine/arginine-rich splicing factor 6
DEG_APCC_KENBOX_2
281:285
PKENG
APC,CDC20,FZR1
0.9967
More...
Q8N4B1
Sesquipedalian-1
DEG_APCC_KENBOX_2
183:187
PKENG
APC,CDC20,FZR1
0.9238
More...