DegronMD - Q13277(STX3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K100N	TCGA-23-1121	OV	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation blocking ubiquitination signal	0.75
p.K100N	DO28731	OV	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation blocking ubiquitination signal	0.75
p.K94T	TCGA-AA-3984	COAD	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.6195
p.K94T	TCGA-AX-A0J0	UCEC	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.6195
p.K94T	DO9002	COAD	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.6195
p.K94T	DO41133	UCEC	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.6195
p.R87M	TCGA-D3-A1Q3	SKCM	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.2222
p.R87M	DO47509	SKCM	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.2222
p.N90K	TCGA-F5-6813	READ	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.3056
p.N90K	DO36400	READ	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.3056
p.N90K	SIDM00779	Colorectal Carcinoma	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.3056
p.N90K	NCI-H716	large intestine	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.3056
p.T81M	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.0556
p.T81M	ACH-000795	Leukemia	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.0556
p.T81M	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.0556
p.R92Q	SIDM01099	Neuroblastoma	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.7329
p.R92Q	ACH-000341	Neuroblastoma	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.7329
p.R92Q	SK-N-FI	autonomic ganglia	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.7329
p.E106D	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation rewiring degron network	0.1389
p.N93K	ACH-000634	Brain Cancer	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.5806
p.K86I	ACH-000820	Colon/Colorectal Cancer	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation substituting flanking lysine	0.3056
p.V99M	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	91:99	Mutation altering degron motif	0.7208

Kaplan plot for STX3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STX3

UniProt ID: Q13277

Entrez ID: 6809

Protein name: Syntaxin-3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STX3 in