DegronMD

Uniprot ID: Q13277

Source protein: Syntaxin-3

Source gene: STX3

Class: DEG_APCC_DBOX_1

Location: 91:99

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9289

ASA_SCORE: 79.2556

COIL: 0.0258

CONS_SCORE: 0.4766

DSS_SCORE: 0.4767

HELIX: 0.9761

FCONS_SCORE: 1.5126

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K100N	TCGA-23-1121	OV	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	0.75
p.K100N	DO28731	OV	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	0.75
p.K94T	TCGA-AA-3984	COAD	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	0.6195
p.K94T	TCGA-AX-A0J0	UCEC	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	0.6195
p.K94T	DO9002	COAD	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	0.6195
p.K94T	DO41133	UCEC	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	0.6195
p.R87M	TCGA-D3-A1Q3	SKCM	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	0.2222
p.R87M	DO47509	SKCM	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	0.2222
p.N90K	TCGA-F5-6813	READ	TCGA	VRNKLKSME	DEG_APCC_DBOX_1	0.3056
p.N90K	DO36400	READ	ICGC	VRNKLKSME	DEG_APCC_DBOX_1	0.3056
p.N90K	SIDM00779	Colorectal Carcinoma	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	0.3056
p.N90K	NCI-H716	large_intestine	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	0.3056
p.T81M	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	0.0556
p.T81M	ACH-000795	Leukemia	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	0.0556
p.T81M	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	0.0556
p.R92Q	SIDM01099	Neuroblastoma	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	0.7329
p.R92Q	ACH-000341	Neuroblastoma	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	0.7329
p.R92Q	SK-N-FI	autonomic_ganglia	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	0.7329
p.E106D	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	VRNKLKSME	DEG_APCC_DBOX_1	0.1389
p.N93K	ACH-000634	Brain Cancer	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	0.5806
p.K86I	ACH-000820	Colon/Colorectal Cancer	CCLE	VRNKLKSME	DEG_APCC_DBOX_1	0.3056
p.V99M	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VRNKLKSME	DEG_APCC_DBOX_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13277	Syntaxin-3	DEG_APCC_DBOX_1	91:99	VRNKLKSME	APC,CDC20,FZR1	0.9289	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons