DegronMD - Q13308(PTK7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R475H	TCGA-31-1950	OV	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1389
p.R475H	SIDM00980	Gastric Carcinoma	GDSC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1389
p.R475H	23132-87	stomach	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1389
p.V479M	TCGA-A5-A1OF	UCEC	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.25
p.V479M	TCGA-QG-A5Z2	COAD	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.25
p.R488H	TCGA-B5-A3FC	UCEC	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation altering degron motif	0.8244
p.E499K	TCGA-BF-AAP7	SKCM	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.0556
p.E499K	TCGA-FW-A3R5	SKCM	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.0556
p.S478N	TCGA-DU-6407	LGG	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.2222
p.G484V	TCGA-VQ-A8PB	STAD	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation altering degron motif	0.7532
p.A494T	DO8103	COAD	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1944
p.V496F	DO228971	LICA	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1389
p.V496F	DO45476	LUSC	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1389
p.R495L	DO229006	LICA	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1667
p.E491K	DO37406	SKCM	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.2778
p.E491K	DO219472	SKCM	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.2778
p.G476V	DO51766	STAD	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.1667
p.R480H	DO41871	UCEC	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.2778
p.A492V	ACH-000990	Endometrial/Uterine Cancer	CCLE	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.25
p.G487R	EKVX	lung	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation altering degron motif	0.7568
p.T478R	SW1573	lung	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.2222
p.L480I	NCI-H1155	lung	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	482:489	Mutation rewiring degron network	0.2778

Kaplan plot for PTK7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PTK7

UniProt ID: Q13308

Entrez ID: 5754

Protein name: Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PTK7 in