DegronMD

Uniprot ID: Q13308

Source protein: Inactive tyrosine-protein kinase 7

Source gene: PTK7

Class: DEG_SCF_FBW7_1

Location: 482:489

E3 ligase: FBXW7

DEGRON score: 0.5048

ASA_SCORE: 52.3125

COIL: 0.3796

CONS_SCORE: 0.4371

DSS_SCORE: 0.2729

HELIX: 0.003

FCONS_SCORE: 0.9393

RIG_SCORE: 0.7369

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R488H	TCGA-B5-A3FC	UCEC	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.8244
p.G487R	EKVX	lung	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	0.7568
p.G484V	TCGA-VQ-A8PB	STAD	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.7532
p.E491K	DO37406	SKCM	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.2778
p.E491K	DO219472	SKCM	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.2778
p.R480H	DO41871	UCEC	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.2778
p.L480I	NCI-H1155	lung	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	0.2778
p.V479M	TCGA-A5-A1OF	UCEC	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.25
p.V479M	TCGA-QG-A5Z2	COAD	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.25
p.A492V	ACH-000990	Endometrial/Uterine Cancer	CCLE	MSSTPAGS	DEG_SCF_FBW7_1	0.25
p.S478N	TCGA-DU-6407	LGG	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.2222
p.T478R	SW1573	lung	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	0.2222
p.A494T	DO8103	COAD	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.1944
p.R495L	DO229006	LICA	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.1667
p.G476V	DO51766	STAD	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.1667
p.R475H	TCGA-31-1950	OV	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.1389
p.R475H	SIDM00980	Gastric Carcinoma	GDSC	MSSTPAGS	DEG_SCF_FBW7_1	0.1389
p.R475H	23132-87	stomach	COSMIC	MSSTPAGS	DEG_SCF_FBW7_1	0.1389
p.V496F	DO228971	LICA	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.1389
p.V496F	DO45476	LUSC	ICGC	MSSTPAGS	DEG_SCF_FBW7_1	0.1389
p.E499K	TCGA-BF-AAP7	SKCM	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.0556
p.E499K	TCGA-FW-A3R5	SKCM	TCGA	MSSTPAGS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13308	Inactive tyrosine-protein kinase 7	DEG_SCF_FBW7_1	482:489	MSSTPAGS	FBXW7	0.5048	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons