DegronMD - Q13330(MTA1)

FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q8K4B0, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:17671180, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:24413532}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R531C	TCGA-AA-A01R	COAD	TCGA	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8301
p.R531C	ACH-000963	Colon/Colorectal Cancer	CCLE	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.8301
p.S520F	TCGA-DD-AACQ	LIHC	TCGA	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation blocking phosphorylation signal	0.5
p.R539Q	TCGA-EO-A22U	UCEC	TCGA	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.3056
p.T547M	DO561	BLCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.0833
p.T547M	DO230326	COCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.0833
p.K532Q	DO229218	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.5833
p.K532Q	DO229221	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.5833
p.R546P	DO229211	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation rewiring degron network	0.1111
p.V520M	DO229085	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation blocking phosphorylation signal	0.5
p.V520M	DO42825	UCEC	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation blocking phosphorylation signal	0.5
p.R522Q	DO43755	UCEC	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation blocking phosphorylation signal	0.5556
p.V537M	SIDM02039	Colorectal Carcinoma	GDSC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.6097
p.V536M	ACH-000960	Leukemia	CCLE	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7208
p.V536M	REH	haematopoietic and lymphoid tissue	COSMIC	VRKPLEAVL	DEG_APCC_DBOX_1	530:538	Mutation altering degron motif	0.7208

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MTA1

UniProt ID: Q13330

Entrez ID: 9112

Protein name: Metastasis-associated protein MTA1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MTA1 in