DegronMD

Uniprot ID: Q13330

Source protein: Metastasis-associated protein MTA1

Source gene: MTA1

Class: DEG_APCC_DBOX_1

Location: 530:538

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8454

ASA_SCORE: 67.2111

COIL: 0.406

CONS_SCORE: 0.418

DSS_SCORE: 0.3021

HELIX: 0.5616

FCONS_SCORE: 1.0211

RIG_SCORE: 0.7858

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R531C	TCGA-AA-A01R	COAD	TCGA	VRKPLEAVL	DEG_APCC_DBOX_1	0.8301
p.R531C	ACH-000963	Colon/Colorectal Cancer	CCLE	VRKPLEAVL	DEG_APCC_DBOX_1	0.8301
p.V536M	ACH-000960	Leukemia	CCLE	VRKPLEAVL	DEG_APCC_DBOX_1	0.7208
p.V536M	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VRKPLEAVL	DEG_APCC_DBOX_1	0.7208
p.V537M	SIDM02039	Colorectal Carcinoma	GDSC	VRKPLEAVL	DEG_APCC_DBOX_1	0.6097
p.K532Q	DO229218	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.5833
p.K532Q	DO229221	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.5833
p.R522Q	DO43755	UCEC	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.5556
p.S520F	TCGA-DD-AACQ	LIHC	TCGA	VRKPLEAVL	DEG_APCC_DBOX_1	0.5
p.V520M	DO229085	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.5
p.V520M	DO42825	UCEC	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.5
p.R539Q	TCGA-EO-A22U	UCEC	TCGA	VRKPLEAVL	DEG_APCC_DBOX_1	0.3056
p.R546P	DO229211	THCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.1111
p.T547M	DO561	BLCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.0833
p.T547M	DO230326	COCA	ICGC	VRKPLEAVL	DEG_APCC_DBOX_1	0.0833

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13330	Metastasis-associated protein MTA1	DEG_APCC_DBOX_1	530:538	VRKPLEAVL	APC,CDC20,FZR1	0.8454	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons