DegronMD - Q13349(ITGAD)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T696A	TCGA-AA-3984	COAD	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.0833
p.T696A	DO9002	COAD	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.0833
p.T696I	TCGA-AB-2807	LAML	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.0833
p.T696I	DO21589	LAML	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.0833
p.P695S	TCGA-D3-A3C8	SKCM	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.0556
p.P695S	DO47636	SKCM	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.0556
p.D718N	TCGA-EE-A29L	SKCM	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1111
p.D718N	DO222599	MELA	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1111
p.D718N	DO37835	SKCM	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1111
p.R699Q	TCGA-EO-A22R	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1667
p.R699Q	TCGA-QS-A5YQ	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1667
p.R699Q	DO49073	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1667
p.R699Q	DO42713	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1667
p.R699Q	SIDM00234	Other Solid Cancers	GDSC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1667
p.R699Q	ACH-002201	Cervical Cancer	CCLE	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1667
p.R699Q	TC-YIK	cervix	COSMIC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1667
p.T711A	TCGA-EO-A22U	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.3056
p.T711A	DO43755	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.3056
p.R700I	TCGA-EY-A1G8	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1944
p.R700I	DO43578	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1944
p.L697M	DO233145	GACA	ICGC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation rewiring degron network	0.1111
p.G706R	SIDM01265	Plasma Cell Myeloma	GDSC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation altering degron motif	0.6457
p.G706R	SIDM00875	Breast Carcinoma	GDSC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation altering degron motif	0.6457
p.G706R	SIDM00930	Osteosarcoma	GDSC	LGIHCE	LIG_APCC_ABBA_1	705:710	Mutation altering degron motif	0.6457

Kaplan plot for ITGAD in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGAD

UniProt ID: Q13349

Entrez ID: 3681

Protein name: Integrin alpha-D (ADB2) (CD11 antigen-like family member D) (Leukointegrin alpha D) (CD antigen CD11d)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ITGAD in