DegronMD

Uniprot ID: Q13349

Source protein: Integrin alpha-D

Source gene: ITGAD

Class: LIG_APCC_ABBA_1

Location: 705:710

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.529

ASA_SCORE: 68.0667

COIL: 0.544

CONS_SCORE: 0.4091

DSS_SCORE: 0.0527

HELIX: 0.0163

FCONS_SCORE: 0.7715

RIG_SCORE: 0.8635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T696A	TCGA-AA-3984	COAD	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.0833
p.T696A	DO9002	COAD	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.0833
p.T696I	TCGA-AB-2807	LAML	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.0833
p.T696I	DO21589	LAML	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.0833
p.P695S	TCGA-D3-A3C8	SKCM	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.0556
p.P695S	DO47636	SKCM	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.0556
p.D718N	TCGA-EE-A29L	SKCM	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.1111
p.D718N	DO222599	MELA	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.1111
p.D718N	DO37835	SKCM	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.1111
p.R699Q	TCGA-EO-A22R	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.1667
p.R699Q	TCGA-QS-A5YQ	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.1667
p.R699Q	DO49073	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.1667
p.R699Q	DO42713	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.1667
p.R699Q	SIDM00234	Other Solid Cancers	GDSC	LGIHCE	LIG_APCC_ABBA_1	0.1667
p.R699Q	ACH-002201	Cervical Cancer	CCLE	LGIHCE	LIG_APCC_ABBA_1	0.1667
p.R699Q	TC-YIK	cervix	COSMIC	LGIHCE	LIG_APCC_ABBA_1	0.1667
p.T711A	TCGA-EO-A22U	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.3056
p.T711A	DO43755	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.3056
p.R700I	TCGA-EY-A1G8	UCEC	TCGA	LGIHCE	LIG_APCC_ABBA_1	0.1944
p.R700I	DO43578	UCEC	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.1944
p.L697M	DO233145	GACA	ICGC	LGIHCE	LIG_APCC_ABBA_1	0.1111
p.G706R	SIDM01265	Plasma Cell Myeloma	GDSC	LGIHCE	LIG_APCC_ABBA_1	0.6457
p.G706R	SIDM00875	Breast Carcinoma	GDSC	LGIHCE	LIG_APCC_ABBA_1	0.6457
p.G706R	SIDM00930	Osteosarcoma	GDSC	LGIHCE	LIG_APCC_ABBA_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13349	Integrin alpha-D	LIG_APCC_ABBA_1	705:710	LGIHCE	APC,CDC20,FZR1	0.529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons