DegronMD - Q13356(PPIL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T204I	TCGA-59-2349	OV	TCGA	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.5966
p.T204I	DO28621	OV	ICGC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.5966
p.N201S	TCGA-CA-6717	COAD	TCGA	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.25
p.N201S	DO8264	COAD	ICGC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.25
p.Y212N	TCGA-D3-A51E	SKCM	TCGA	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.7059
p.Y212N	DO47465	SKCM	ICGC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.7059
p.T204S	TCGA-DF-A2KU	UCEC	TCGA	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6005
p.T204S	DO223286	UCEC	ICGC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.6005
p.E219K	SIDM00678	Bladder Carcinoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1389
p.E203D	SIDM00216	Colorectal Carcinoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.3056
p.T200A	SIDM00837	Colorectal Carcinoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.2222
p.I220M	SIDM00574	Glioblastoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1111
p.I220M	ACH-001605	Brain Cancer	CCLE	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1111
p.I220M	no-10	central nervous system	COSMIC	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation rewiring degron network	0.1111
p.R205L	ACH-001794	Liposarcoma	CCLE	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.8428
p.R205L	ACH-001795	Liposarcoma	CCLE	TRETLQELY	DEG_APCC_DBOX_1	204:212	Mutation altering degron motif	0.8428

Kaplan plot for PPIL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPIL2

UniProt ID: Q13356

Entrez ID: 23759

Protein name: RING-type E3 ubiquitin-protein ligase PPIL2 (EC 2.3.2.27) (CYC4) (Cyclophilin-60) (Cyclophilin-like protein Cyp-60) (Cyp60) (hCyP-60) (Probable inactive peptidyl-prolyl cis-trans isomerase-like 2) (PPIase) (Rotamase PPIL2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPIL2 in