DegronMD

Uniprot ID: Q13356

Source protein: RING-type E3 ubiquitin-protein ligase PPIL2

Source gene: PPIL2

Class: DEG_APCC_DBOX_1

Location: 204:212

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7596

ASA_SCORE: 75.4222

COIL: 0.0622

CONS_SCORE: 0.225

DSS_SCORE: 0.3964

HELIX: 0.9361

FCONS_SCORE: 1.0684

RIG_SCORE: 0.8166

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T204I	TCGA-59-2349	OV	TCGA	TRETLQELY	DEG_APCC_DBOX_1	0.5966
p.T204I	DO28621	OV	ICGC	TRETLQELY	DEG_APCC_DBOX_1	0.5966
p.N201S	TCGA-CA-6717	COAD	TCGA	TRETLQELY	DEG_APCC_DBOX_1	0.25
p.N201S	DO8264	COAD	ICGC	TRETLQELY	DEG_APCC_DBOX_1	0.25
p.Y212N	TCGA-D3-A51E	SKCM	TCGA	TRETLQELY	DEG_APCC_DBOX_1	0.7059
p.Y212N	DO47465	SKCM	ICGC	TRETLQELY	DEG_APCC_DBOX_1	0.7059
p.T204S	TCGA-DF-A2KU	UCEC	TCGA	TRETLQELY	DEG_APCC_DBOX_1	0.6005
p.T204S	DO223286	UCEC	ICGC	TRETLQELY	DEG_APCC_DBOX_1	0.6005
p.E219K	SIDM00678	Bladder Carcinoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	0.1389
p.E203D	SIDM00216	Colorectal Carcinoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	0.3056
p.T200A	SIDM00837	Colorectal Carcinoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	0.2222
p.I220M	SIDM00574	Glioblastoma	GDSC	TRETLQELY	DEG_APCC_DBOX_1	0.1111
p.I220M	ACH-001605	Brain Cancer	CCLE	TRETLQELY	DEG_APCC_DBOX_1	0.1111
p.I220M	no-10	central_nervous_system	COSMIC	TRETLQELY	DEG_APCC_DBOX_1	0.1111
p.R205L	ACH-001794	Liposarcoma	CCLE	TRETLQELY	DEG_APCC_DBOX_1	0.8428
p.R205L	ACH-001795	Liposarcoma	CCLE	TRETLQELY	DEG_APCC_DBOX_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13356	RING-type E3 ubiquitin-protein ligase PPIL2	DEG_APCC_DBOX_1	204:212	TRETLQELY	APC,CDC20,FZR1	0.7596	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons