DegronMD - Q13368(MPP3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D172N	TCGA-A3-A8OV	KIRC	TCGA	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.5821
p.D172N	DO219232	KIRC	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.5821
p.A170T	TCGA-AP-A0LM	UCEC	TCGA	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.2778
p.A190T	DO227906	COCA	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556
p.A190T	ACH-001328	Skin Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556
p.A190T	A431	skin	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.0556
p.R164C	DO234261	ESAD	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.H178N	DO228985	LICA	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.6312
p.A174D	DO229024	LICA	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.7793
p.S182L	DO25310	LUAD	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.2778
p.L172M	DO47284	SKCM	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.711
p.R164H	DO41331	UCEC	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.I176V	SIDM00955	Melanoma	GDSC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.7076
p.I176V	COLO-783	skin	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.7076
p.R178W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8634
p.R178W	NCI-H1155	lung	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation altering degron motif	0.8634
p.R184Q	ACH-000478	Liver Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.2222
p.R184Q	SNU-387	liver	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.2222
p.G188E	ACH-002396	Bone Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.G188E	Sarc9371	bone	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.G188R	ACH-002396	Bone Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111
p.G188R	Sarc9371	bone	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	172:180	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPP3

UniProt ID: Q13368

Entrez ID: 4356

Protein name: MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPP3 in