DegronMD

Uniprot ID: Q13368

Source protein: MAGUK p55 subfamily member 3

Source gene: MPP3

Class: DEG_APCC_DBOX_1

Location: 172:180

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7625

ASA_SCORE: 59.5444

COIL: 0.7192

CONS_SCORE: 0.6336

DSS_SCORE: 0.3196

HELIX: 0.2048

FCONS_SCORE: 1.0695

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D172N	TCGA-A3-A8OV	KIRC	TCGA	DRSGLVHVG	DEG_APCC_DBOX_1	0.5821
p.D172N	DO219232	KIRC	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.5821
p.A170T	TCGA-AP-A0LM	UCEC	TCGA	DRSGLVHVG	DEG_APCC_DBOX_1	0.2778
p.A190T	DO227906	COCA	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.0556
p.A190T	ACH-001328	Skin Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	0.0556
p.A190T	A431	skin	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	0.0556
p.R164C	DO234261	ESAD	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.1111
p.H178N	DO228985	LICA	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.6312
p.A174D	DO229024	LICA	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.7793
p.S182L	DO25310	LUAD	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.2778
p.L172M	DO47284	SKCM	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.711
p.R164H	DO41331	UCEC	ICGC	DRSGLVHVG	DEG_APCC_DBOX_1	0.1111
p.I176V	SIDM00955	Melanoma	GDSC	DRSGLVHVG	DEG_APCC_DBOX_1	0.7076
p.I176V	COLO-783	skin	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	0.7076
p.R178W	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	DRSGLVHVG	DEG_APCC_DBOX_1	0.8634
p.R178W	NCI-H1155	lung	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	0.8634
p.R184Q	ACH-000478	Liver Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	0.2222
p.R184Q	SNU-387	liver	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	0.2222
p.G188E	ACH-002396	Bone Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	0.1111
p.G188E	Sarc9371	bone	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	0.1111
p.G188R	ACH-002396	Bone Cancer	CCLE	DRSGLVHVG	DEG_APCC_DBOX_1	0.1111
p.G188R	Sarc9371	bone	COSMIC	DRSGLVHVG	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13368	MAGUK p55 subfamily member 3	DEG_APCC_DBOX_1	172:180	DRSGLVHVG	APC,CDC20,FZR1	0.7625	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons