DegronMD - Q13370(PDE3B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G970S	TCGA-22-5485	LUSC	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.25
p.P972A	TCGA-3P-A9WA	OV	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.3056
p.D964Y	TCGA-A5-A0G1	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.0833
p.D964Y	DO229029	LICA	ICGC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.0833
p.D964Y	DO42472	UCEC	ICGC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.0833
p.R979H	TCGA-AX-A1CE	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.3056
p.R979H	DO42280	UCEC	ICGC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.3056
p.G963V	TCGA-D3-A2JP	SKCM	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.0556
p.A967T	TCGA-F5-6814	READ	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1667
p.A967T	DO36556	READ	ICGC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1667
p.L969I	TCGA-F5-6814	READ	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.2222
p.I973V	TCGA-FI-A2D5	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation altering degron motif	0.5965
p.G979S	DO7828	COAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.3056
p.G979S	DO234336	ESAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.3056
p.L969V	SIDM01128	Small Cell Lung Carcinoma	GDSC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.2222
p.L969V	NCI-H526	lung	COSMIC	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.2222
p.S980F	ACH-000842	Colon/Colorectal Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.2778
p.D976N	ACH-000929	Lung Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	973:978	Mutation altering degron motif	0.6932

Kaplan plot for PDE3B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE3B

UniProt ID: Q13370

Entrez ID: 5140

Protein name: cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (CGIPDE1) (CGIP1) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE3B in