DegronMD

Uniprot ID: Q13370

Source protein: cGMP-inhibited 3',5'-cyclic phosphodiesterase B

Source gene: PDE3B

Class: LIG_APCC_ABBA_1

Location: 973:978

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9865

ASA_SCORE: 44.6833

COIL: 0.787

CONS_SCORE: 0.6084

DSS_SCORE: 0.3816

HELIX: 0.0818

FCONS_SCORE: 1.0345

RIG_SCORE: 0.7717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G970S	TCGA-22-5485	LUSC	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.25
p.P972A	TCGA-3P-A9WA	OV	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.D964Y	TCGA-A5-A0G1	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.0833
p.D964Y	DO229029	LICA	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.0833
p.D964Y	DO42472	UCEC	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.0833
p.R979H	TCGA-AX-A1CE	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R979H	DO42280	UCEC	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.G963V	TCGA-D3-A2JP	SKCM	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.0556
p.A967T	TCGA-F5-6814	READ	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.1667
p.A967T	DO36556	READ	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.1667
p.L969I	TCGA-F5-6814	READ	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.2222
p.I973V	TCGA-FI-A2D5	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.5965
p.G979S	DO7828	COAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.G979S	DO234336	ESAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.L969V	SIDM01128	Small Cell Lung Carcinoma	GDSC	ISPFMD	LIG_APCC_ABBA_1	0.2222
p.L969V	NCI-H526	lung	COSMIC	ISPFMD	LIG_APCC_ABBA_1	0.2222
p.S980F	ACH-000842	Colon/Colorectal Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	0.2778
p.D976N	ACH-000929	Lung Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13370	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	LIG_APCC_ABBA_1	973:978	ISPFMD	APC,CDC20,FZR1	0.9865	More...
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	LIG_APCC_ABBA_1	986:991	ISPFMD	APC,CDC20,FZR1	0.8601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons