DegronMD - Q14432(PDE3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1000I	TCGA-17-Z055	LUAD	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.0833
p.H308R	TCGA-2W-A8YY	CESC	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.H308R	DO223732	CESC	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.R992C	TCGA-2W-A8YY	CESC	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.R992C	TCGA-EI-6917	READ	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.R992C	TCGA-FW-A3R5	SKCM	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.R992C	DO223732	CESC	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.R992C	DO36881	READ	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.R992C	DO37406	SKCM	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.G302C	TCGA-49-AARE	LUAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1389
p.G302C	DO218922	LUAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1389
p.E978D	TCGA-50-5930	LUAD	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1111
p.E978D	DO25189	LUAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1111
p.E299G	TCGA-55-8205	LUAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.E299G	DO48884	LUAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.R992H	TCGA-AP-A1DV	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.R992H	DO233732	GACA	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.R992H	DO43186	UCEC	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.3056
p.G976A	TCGA-BA-4076	HNSC	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.0556
p.A980D	TCGA-BR-4292	STAD	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1667
p.A980D	DO38495	STAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1667
p.W327C	TCGA-C5-A1MN	CESC	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.W327C	DO6257	CESC	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.Q1001H	TCGA-D8-A1JK	BRCA	TCGA	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.0556
p.Q1001H	DO3880	BRCA	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.0556
p.A471T	TCGA-ED-A7XO	LIHC	TCGA	APSSS	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.7139
p.A471T	DO48496	LIHC	ICGC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.7139
p.P482L	TCGA-EE-A2A2	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1389
p.P482L	DO37583	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1389
p.P529H	TCGA-EO-A22R	UCEC	TCGA	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.3056
p.P529H	DO45299	LIRI	ICGC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.3056
p.P529H	DO42713	UCEC	ICGC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.3056
p.M485I	TCGA-ER-A19P	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0556
p.M485I	DO47623	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0556
p.G323R	TCGA-EY-A1H0	UCEC	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1667
p.G323R	DO43114	UCEC	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1667
p.S527F	TCGA-FW-A3R5	SKCM	TCGA	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking phosphorylation signal	0.6944
p.S527F	DO37406	SKCM	ICGC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking phosphorylation signal	0.6944
p.S527F	SIDM00850	Gastric Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking phosphorylation signal	0.6944
p.S527F	ACH-000880	Gastric Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking phosphorylation signal	0.6944
p.S527F	AGS	stomach	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking phosphorylation signal	0.6944
p.P317S	TCGA-IB-7651	PAAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.5641
p.P317S	DO46657	PAAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.5641
p.A471V	TCGA-IB-7651	PAAD	TCGA	APSSS	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5825
p.A471V	DO46657	PAAD	ICGC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation altering degron motif	0.5825
p.S301F	TCGA-VQ-A8DT	STAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation blocking phosphorylation signal	0.5556
p.S301F	DO51751	STAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation blocking phosphorylation signal	0.5556
p.S523L	TCGA-VS-A8QA	CESC	TCGA	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking phosphorylation signal	0.5833
p.S523L	DO51627	CESC	ICGC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking phosphorylation signal	0.5833
p.S463N	TCGA-VS-A9U6	CESC	TCGA	APSSS	DEG_SPOP_SBC_1	471:475	Mutation blocking phosphorylation signal	0.5556
p.S463N	DO219728	CESC	ICGC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation blocking phosphorylation signal	0.5556
p.R309W	TCGA-ZF-AA58	BLCA	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7523
p.R309W	DO219100	BLCA	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7523
p.S312P	DO225012	BRCA	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6752
p.A535T	DO222905	BTCA	ICGC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation altering degron motif	0.6028
p.V539L	DO50406	ESAD	ICGC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.2778
p.D991Y	DO233253	GACA	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation altering degron motif	0.7325
p.M990I	DO233253	GACA	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation altering degron motif	0.6507
p.C303Y	DO233697	GACA	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1667
p.V545L	DO231078	LUSC	ICGC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1111
p.V483M	DO50702	ORCA	ICGC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1111
p.V483M	ACH-001416	Bladder Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.1111
p.R462H	DO34280	PACA	ICGC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.P995S	DO218884	SKCA	ICGC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.2222
p.E979Q	SIDM02031	Esophageal Carcinoma	GDSC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1389
p.Q996L	SIDM00643	Non-Cancerous	GDSC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1944
p.Q996L	ACH-000327	Lung Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1944
p.Q996L	ACH-002363	Non-Cancerous	CCLE	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.1944
p.R309Q	SIDM00945	Colorectal Carcinoma	GDSC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6218
p.R309Q	ACH-000895	Colon/Colorectal Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6218
p.R309Q	CL-34	large intestine	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6218
p.I542M	SIDM00193	Colorectal Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1944
p.I542M	ACH-000991	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1944
p.I542M	SNU-81	large intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.1944
p.Q546R	SIDM00660	Colorectal Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0833
p.Q546R	ACH-000985	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0833
p.Q546R	LS-411N	large intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.0833
p.C315F	SIDM00489	Oral Cavity Carcinoma	GDSC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.5996
p.C315F	ACH-002043	Head and Neck Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.5996
p.C315F	Ca9-22	upper aerodigestive tract	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.5996
p.S478F	SIDM00272	Breast Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation blocking phosphorylation signal	0.6944
p.G302S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1389
p.G302S	ACH-000938	Leukemia	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1389
p.G302S	NALM-6	haematopoietic and lymphoid tissue	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1389
p.R462C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.R462C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0833
p.D977N	SIDM00006	Other Solid Cancers	GDSC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.0833
p.D977N	ACH-001552	Skin Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.0833
p.D977N	MCC26	skin	COSMIC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation rewiring degron network	0.0833
p.S987N	SIDM00999	Bladder Carcinoma	GDSC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation altering degron motif	0.5958
p.S987N	ACH-000973	Bladder Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation altering degron motif	0.5958
p.S987N	639-V	urinary tract	COSMIC	ISPFMD	LIG_APCC_ABBA_1	986:991	Mutation altering degron motif	0.5958
p.K541T	SIDM00118	Colorectal Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking ubiquitination signal	0.6667
p.K541T	ACH-001081	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking ubiquitination signal	0.6667
p.K541T	HCC2998	large intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation blocking ubiquitination signal	0.6667
p.M485V	SIDM00531	Pancreatic Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0556
p.M485V	HuP-T4	pancreas	COSMIC	APSSS	DEG_SPOP_SBC_1	471:475	Mutation rewiring degron network	0.0556
p.I316M	ACH-000982	Colon/Colorectal Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6507
p.I316M	ACH-001345	Colon/Colorectal Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6507
p.I316M	GP5d	large intestine	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6507
p.V539A	ACH-000997	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.2778
p.V539A	ACH-001061	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.2778
p.V539A	HCT-15	large intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	530:537	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDE3A

UniProt ID: Q14432

Entrez ID: 5139

Protein name: cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A) (cGMP-inhibited cAMP phosphodiesterase) (cGI-PDE)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDE3A in