DegronMD

Uniprot ID: Q14432

Source protein: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Source gene: PDE3A

Class: DEG_SCF_FBW7_1

Location: 530:537

E3 ligase: FBXW7

DEGRON score: 0.9778

ASA_SCORE: 72.375

COIL: 0.8355

CONS_SCORE: 0.3676

DSS_SCORE: 0.4317

HELIX: 0.0991

FCONS_SCORE: 0.9396

RIG_SCORE: 0.624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P529H	TCGA-EO-A22R	UCEC	TCGA	LQGTPASS	DEG_SCF_FBW7_1	0.3056
p.P529H	DO45299	LIRI	ICGC	LQGTPASS	DEG_SCF_FBW7_1	0.3056
p.P529H	DO42713	UCEC	ICGC	LQGTPASS	DEG_SCF_FBW7_1	0.3056
p.S527F	TCGA-FW-A3R5	SKCM	TCGA	LQGTPASS	DEG_SCF_FBW7_1	0.6944
p.S527F	DO37406	SKCM	ICGC	LQGTPASS	DEG_SCF_FBW7_1	0.6944
p.S527F	SIDM00850	Gastric Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	0.6944
p.S527F	ACH-000880	Gastric Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	0.6944
p.S527F	AGS	stomach	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	0.6944
p.S523L	TCGA-VS-A8QA	CESC	TCGA	LQGTPASS	DEG_SCF_FBW7_1	0.5833
p.S523L	DO51627	CESC	ICGC	LQGTPASS	DEG_SCF_FBW7_1	0.5833
p.A535T	DO222905	BTCA	ICGC	LQGTPASS	DEG_SCF_FBW7_1	0.6028
p.V539L	DO50406	ESAD	ICGC	LQGTPASS	DEG_SCF_FBW7_1	0.2778
p.V545L	DO231078	LUSC	ICGC	LQGTPASS	DEG_SCF_FBW7_1	0.1111
p.I542M	SIDM00193	Colorectal Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	0.1944
p.I542M	ACH-000991	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	0.1944
p.I542M	SNU-81	large_intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	0.1944
p.Q546R	SIDM00660	Colorectal Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	0.0833
p.Q546R	ACH-000985	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	0.0833
p.Q546R	LS-411N	large_intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	0.0833
p.K541T	SIDM00118	Colorectal Carcinoma	GDSC	LQGTPASS	DEG_SCF_FBW7_1	0.6667
p.K541T	ACH-001081	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	0.6667
p.K541T	HCC2998	large_intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	0.6667
p.V539A	ACH-000997	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	0.2778
p.V539A	ACH-001061	Colon/Colorectal Cancer	CCLE	LQGTPASS	DEG_SCF_FBW7_1	0.2778
p.V539A	HCT-15	large_intestine	COSMIC	LQGTPASS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	DEG_SCF_FBW7_1	530:537	LQGTPASS	FBXW7	0.9778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQGTPASS

Degron related mutations and impact score

Drug responses associated with PDE3A mutations

All proteins holding degron of LQGTPASS