DegronMD

Uniprot ID: Q14432

Source protein: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Source gene: PDE3A

Class: LIG_APCC_ABBA_1

Location: 986:991

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8601

ASA_SCORE: 42.5

COIL: 0.7863

CONS_SCORE: 0.6325

DSS_SCORE: 0.3534

HELIX: 0.1198

FCONS_SCORE: 1.0367

RIG_SCORE: 0.7782

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1000I	TCGA-17-Z055	LUAD	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.0833
p.R992C	TCGA-2W-A8YY	CESC	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R992C	TCGA-EI-6917	READ	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R992C	TCGA-FW-A3R5	SKCM	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R992C	DO223732	CESC	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R992C	DO36881	READ	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R992C	DO37406	SKCM	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.E978D	TCGA-50-5930	LUAD	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.1111
p.E978D	DO25189	LUAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.1111
p.R992H	TCGA-AP-A1DV	UCEC	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R992H	DO233732	GACA	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.R992H	DO43186	UCEC	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.3056
p.G976A	TCGA-BA-4076	HNSC	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.0556
p.A980D	TCGA-BR-4292	STAD	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.1667
p.A980D	DO38495	STAD	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.1667
p.Q1001H	TCGA-D8-A1JK	BRCA	TCGA	ISPFMD	LIG_APCC_ABBA_1	0.0556
p.Q1001H	DO3880	BRCA	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.0556
p.D991Y	DO233253	GACA	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.7325
p.M990I	DO233253	GACA	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.6507
p.P995S	DO218884	SKCA	ICGC	ISPFMD	LIG_APCC_ABBA_1	0.2222
p.E979Q	SIDM02031	Esophageal Carcinoma	GDSC	ISPFMD	LIG_APCC_ABBA_1	0.1389
p.Q996L	SIDM00643	Non-Cancerous	GDSC	ISPFMD	LIG_APCC_ABBA_1	0.1944
p.Q996L	ACH-000327	Lung Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	0.1944
p.Q996L	ACH-002363	Non-Cancerous	CCLE	ISPFMD	LIG_APCC_ABBA_1	0.1944
p.D977N	SIDM00006	Other Solid Cancers	GDSC	ISPFMD	LIG_APCC_ABBA_1	0.0833
p.D977N	ACH-001552	Skin Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	0.0833
p.D977N	MCC26	skin	COSMIC	ISPFMD	LIG_APCC_ABBA_1	0.0833
p.S987N	SIDM00999	Bladder Carcinoma	GDSC	ISPFMD	LIG_APCC_ABBA_1	0.5958
p.S987N	ACH-000973	Bladder Cancer	CCLE	ISPFMD	LIG_APCC_ABBA_1	0.5958
p.S987N	639-V	urinary_tract	COSMIC	ISPFMD	LIG_APCC_ABBA_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13370	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	LIG_APCC_ABBA_1	973:978	ISPFMD	APC,CDC20,FZR1	0.9865	More...
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	LIG_APCC_ABBA_1	986:991	ISPFMD	APC,CDC20,FZR1	0.8601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISPFMD

Degron related mutations and impact score

Drug responses associated with PDE3A mutations

All proteins holding degron of ISPFMD