DegronMD

Uniprot ID: Q14432

Source protein: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Source gene: PDE3A

Class: DEG_APCC_DBOX_1

Location: 309:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9986

ASA_SCORE: 69.7778

COIL: 0.8113

CONS_SCORE: 0.3951

DSS_SCORE: 0.5875

HELIX: 0.0313

FCONS_SCORE: 1.1533

RIG_SCORE: 0.7004

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H308R	TCGA-2W-A8YY	CESC	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.3056
p.H308R	DO223732	CESC	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.3056
p.G302C	TCGA-49-AARE	LUAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.1389
p.G302C	DO218922	LUAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.1389
p.E299G	TCGA-55-8205	LUAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.0556
p.E299G	DO48884	LUAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.0556
p.W327C	TCGA-C5-A1MN	CESC	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.0556
p.W327C	DO6257	CESC	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.0556
p.G323R	TCGA-EY-A1H0	UCEC	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.1667
p.G323R	DO43114	UCEC	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.1667
p.P317S	TCGA-IB-7651	PAAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.5641
p.P317S	DO46657	PAAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.5641
p.S301F	TCGA-VQ-A8DT	STAD	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.5556
p.S301F	DO51751	STAD	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.5556
p.R309W	TCGA-ZF-AA58	BLCA	TCGA	RRTSLPCIP	DEG_APCC_DBOX_1	0.7523
p.R309W	DO219100	BLCA	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.7523
p.S312P	DO225012	BRCA	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.6752
p.C303Y	DO233697	GACA	ICGC	RRTSLPCIP	DEG_APCC_DBOX_1	0.1667
p.R309Q	SIDM00945	Colorectal Carcinoma	GDSC	RRTSLPCIP	DEG_APCC_DBOX_1	0.6218
p.R309Q	ACH-000895	Colon/Colorectal Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	0.6218
p.R309Q	CL-34	large_intestine	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	0.6218
p.C315F	SIDM00489	Oral Cavity Carcinoma	GDSC	RRTSLPCIP	DEG_APCC_DBOX_1	0.5996
p.C315F	ACH-002043	Head and Neck Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	0.5996
p.C315F	Ca9-22	upper_aerodigestive_tract	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	0.5996
p.G302S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	RRTSLPCIP	DEG_APCC_DBOX_1	0.1389
p.G302S	ACH-000938	Leukemia	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	0.1389
p.G302S	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	0.1389
p.I316M	ACH-000982	Colon/Colorectal Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	0.6507
p.I316M	ACH-001345	Colon/Colorectal Cancer	CCLE	RRTSLPCIP	DEG_APCC_DBOX_1	0.6507
p.I316M	GP5d	large_intestine	COSMIC	RRTSLPCIP	DEG_APCC_DBOX_1	0.6507

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRTSLPCIP

Degron related mutations and impact score

Drug responses associated with PDE3A mutations

All proteins holding degron of RRTSLPCIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14432	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	DEG_APCC_DBOX_1	309:317	RRTSLPCIP	APC,CDC20,FZR1	0.9986	More...