DegronMD - Q13371(PDCL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H27N	TCGA-A2-A25B	BRCA	TCGA	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.H27N	DO2706	BRCA	ICGC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.E51K	TCGA-A5-A1OF	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.E51K	TCGA-IN-7808	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.E51K	DO38200	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.E51K	DO42568	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0556
p.E28K	TCGA-AA-3864	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0833
p.E28K	DO8490	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0833
p.E28K	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0833
p.E28K	KYSE-140	oesophagus	COSMIC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.0833
p.D190N	TCGA-MP-A4T7	LUAD	TCGA	VHIYED	LIG_APCC_ABBA_1	185:190	Mutation altering degron motif	0.6932
p.D190N	DO45370	LUAD	ICGC	VHIYED	LIG_APCC_ABBA_1	185:190	Mutation altering degron motif	0.6932
p.E45Q	TCGA-N9-A4Q7	UCS	TCGA	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.C35Y	DO233254	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2778
p.M184L	DO228531	LICA	ICGC	VHIYED	LIG_APCC_ABBA_1	185:190	Mutation rewiring degron network	0.3056
p.P193Q	DO229027	LICA	ICGC	VHIYED	LIG_APCC_ABBA_1	185:190	Mutation rewiring degron network	0.25
p.D29E	DO229041	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1111
p.S180N	DO46493	OV	ICGC	VHIYED	LIG_APCC_ABBA_1	185:190	Mutation rewiring degron network	0.1944

Kaplan plot for PDCL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDCL

UniProt ID: Q13371

Entrez ID: 5082

Protein name: Phosducin-like protein (PHLP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDCL in