DegronMD

Uniprot ID: Q13371

Source protein: Phosducin-like protein

Source gene: PDCL

Class: LIG_APCC_ABBA_1

Location: 185:190

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5284

ASA_SCORE: 25.3167

COIL: 0.3565

CONS_SCORE: 0.6187

DSS_SCORE: 0.1284

HELIX: 0.026

FCONS_SCORE: 1.2558

RIG_SCORE: 0.9071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D190N	TCGA-MP-A4T7	LUAD	TCGA	VHIYED	LIG_APCC_ABBA_1	0.6932
p.D190N	DO45370	LUAD	ICGC	VHIYED	LIG_APCC_ABBA_1	0.6932
p.M184L	DO228531	LICA	ICGC	VHIYED	LIG_APCC_ABBA_1	0.3056
p.P193Q	DO229027	LICA	ICGC	VHIYED	LIG_APCC_ABBA_1	0.25
p.S180N	DO46493	OV	ICGC	VHIYED	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13371	Phosducin-like protein	LIG_APCC_ABBA_1	185:190	VHIYED	APC,CDC20,FZR1	0.5284	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons