MAPK8IP2
UniProt ID: Q13387
Entrez ID: 23542
Protein name: C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator...
FUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
behavioral fear response [GO:0001662]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; mating behavior [GO:0007617]; negative regulation of apoptotic signaling pathway [GO:2001234]; nonassociative learning [GO:...
behavioral fear response [GO:0001662]; dendrite morphogenesis [GO:0048813]; excitatory postsynaptic potential [GO:0060079]; JNK cascade [GO:0007254]; MAPK cascade [GO:0000165]; mating behavior [GO:0007617]; negative regulation of apoptotic signaling pathway [GO:2001234]; nonassociative learning [GO:0046958]; positive regulation of stress-activated MAPK cascade [GO:0032874]; regulation of AMPA receptor activity [GO:2000311]; regulation of JNK cascade [GO:0046328]; regulation of NMDA receptor activity [GO:2000310]; regulation of signaling receptor activity [GO:0010469]; regulation of synaptic transmission, glutamatergic [GO:0051966]; signal complex assembly [GO:0007172]; social behavior [GO:0035176]
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GO - Molecular function (MF):
amyloid-beta binding [GO:0001540]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein-containing complex binding [GO:0044877]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198]...
amyloid-beta binding [GO:0001540]; kinesin binding [GO:0019894]; MAP-kinase scaffold activity [GO:0005078]; protein-containing complex binding [GO:0044877]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; structural molecule activity [GO:0005198]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]...
cytoplasm [GO:0005737]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]
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MAPK8IP2
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Kaplan plot for MAPK8IP2 in
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*NOTE: the Kaplan plots were collected from OncoLnc