DegronMD

Uniprot ID: Q13387

Source protein: C-Jun-amino-terminal kinase-interacting protein 2

Source gene: MAPK8IP2

Class: DEG_SCF_TRCP1_1

Location: 539:545

E3 ligase: BTRC

DEGRON score: 0.7747

ASA_SCORE: 68.4429

COIL: 0.8214

CONS_SCORE: 0.3482

DSS_SCORE: 0.7561

HELIX: 0.1431

FCONS_SCORE: 0.8722

RIG_SCORE: 0.587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G555S	TCGA-BR-8078	STAD	TCGA	DSGGEAS	DEG_SCF_TRCP1_1	0.0556
p.E537D	TCGA-D3-A2JC	SKCM	TCGA	DSGGEAS	DEG_SCF_TRCP1_1	0.2778
p.A550T	TCGA-N7-A4Y0	UCS	TCGA	DSGGEAS	DEG_SCF_TRCP1_1	0.1944
p.E534G	DO222798	COCA	ICGC	DSGGEAS	DEG_SCF_TRCP1_1	0.1944
p.N540T	DO41542	UCEC	ICGC	DSGGEAS	DEG_SCF_TRCP1_1	0.7055
p.G541S	SIDM00434	Plasma Cell Myeloma	GDSC	DSGGEAS	DEG_SCF_TRCP1_1	0.6993
p.G541S	SIDM00607	Glioblastoma	GDSC	DSGGEAS	DEG_SCF_TRCP1_1	0.6993
p.G541S	SIDM00579	Neuroblastoma	GDSC	DSGGEAS	DEG_SCF_TRCP1_1	0.6993
p.G541S	SIDM01753	Gastric Carcinoma	GDSC	DSGGEAS	DEG_SCF_TRCP1_1	0.6993
p.G541S	KNS-42	central_nervous_system	COSMIC	DSGGEAS	DEG_SCF_TRCP1_1	0.6993
p.G541S	NB(TU)1-10	autonomic_ganglia	COSMIC	DSGGEAS	DEG_SCF_TRCP1_1	0.6993
p.G541S	MOLP-8	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGEAS	DEG_SCF_TRCP1_1	0.6993
p.E548V	SIDM01119	Other Solid Cancers	GDSC	DSGGEAS	DEG_SCF_TRCP1_1	0.25
p.E548V	NCI-H727	lung	COSMIC	DSGGEAS	DEG_SCF_TRCP1_1	0.25
p.E546V	SIDM01198	Burkitt's Lymphoma	GDSC	DSGGEAS	DEG_SCF_TRCP1_1	0.3056
p.E546V	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGEAS	DEG_SCF_TRCP1_1	0.3056
p.A549V	SIDM00999	Bladder Carcinoma	GDSC	DSGGEAS	DEG_SCF_TRCP1_1	0.2222
p.A549V	639-V	urinary_tract	COSMIC	DSGGEAS	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13387	C-Jun-amino-terminal kinase-interacting protein 2	DEG_SCF_TRCP1_1	539:545	DSGGEAS	BTRC	0.7747	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons