DegronMD - Q13402(MYO7A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1641K	TCGA-AG-A02N	READ	TCGA	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.7022
p.E1641K	DO37146	READ	ICGC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.7022
p.G1651V	TCGA-DU-6392	LGG	TCGA	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.0556
p.G1651V	DO22237	LGG	ICGC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.0556
p.G1630R	TCGA-FW-A3R5	SKCM	TCGA	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.1667
p.G1630R	TCGA-IB-7651	PAAD	TCGA	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.1667
p.G1630R	DO46657	PAAD	ICGC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.1667
p.G1630R	DO37406	SKCM	ICGC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.1667
p.D1636N	DO234281	ESAD	ICGC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.5821
p.W1648C	DO229025	LICA	ICGC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.1389
p.D1638E	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.5647
p.D1638E	KYSE-140	oesophagus	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.5647
p.L1632F	SIDM01608	Endometrial Carcinoma	GDSC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.2222
p.P1633S	ACH-000124	Lymphoma	CCLE	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.25
p.P1633S	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.25
p.P1639L	ACH-000239	Gastric Cancer	CCLE	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.7582
p.P1650H	ACH-000774	Lung Cancer	CCLE	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.0833
p.R1640W	ACH-000938	Leukemia	CCLE	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.8634
p.R1640W	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.8634
p.R1629W	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation substituting flanking lysine	0.25
p.R1647W	CW-2	large intestine	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.1667
p.P1628Q	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.1111
p.P1639Q	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation altering degron motif	0.7035
p.V1645I	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	1636:1641	Mutation rewiring degron network	0.2222

Kaplan plot for MYO7A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYO7A

UniProt ID: Q13402

Entrez ID: 4647

Protein name: Unconventional myosin-VIIa

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MYO7A in