DegronMD

Uniprot ID: Q13402

Source protein: Unconventional myosin-VIIa

Source gene: MYO7A

Class: DEG_Kelch_Keap1_1

Location: 1636:1641

E3 ligase: KEAP1

DEGRON score: 0.9977

ASA_SCORE: 68.5833

COIL: 0.7857

CONS_SCORE: 0.2993

DSS_SCORE: 0.3655

HELIX: 0.0322

FCONS_SCORE: 0.5744

RIG_SCORE: 0.7911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1641K	TCGA-AG-A02N	READ	TCGA	DHDTGE	DEG_Kelch_Keap1_1	0.7022
p.E1641K	DO37146	READ	ICGC	DHDTGE	DEG_Kelch_Keap1_1	0.7022
p.G1651V	TCGA-DU-6392	LGG	TCGA	DHDTGE	DEG_Kelch_Keap1_1	0.0556
p.G1651V	DO22237	LGG	ICGC	DHDTGE	DEG_Kelch_Keap1_1	0.0556
p.G1630R	TCGA-FW-A3R5	SKCM	TCGA	DHDTGE	DEG_Kelch_Keap1_1	0.1667
p.G1630R	TCGA-IB-7651	PAAD	TCGA	DHDTGE	DEG_Kelch_Keap1_1	0.1667
p.G1630R	DO46657	PAAD	ICGC	DHDTGE	DEG_Kelch_Keap1_1	0.1667
p.G1630R	DO37406	SKCM	ICGC	DHDTGE	DEG_Kelch_Keap1_1	0.1667
p.D1636N	DO234281	ESAD	ICGC	DHDTGE	DEG_Kelch_Keap1_1	0.5821
p.W1648C	DO229025	LICA	ICGC	DHDTGE	DEG_Kelch_Keap1_1	0.1389
p.D1638E	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	DHDTGE	DEG_Kelch_Keap1_1	0.5647
p.D1638E	KYSE-140	oesophagus	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.5647
p.L1632F	SIDM01608	Endometrial Carcinoma	GDSC	DHDTGE	DEG_Kelch_Keap1_1	0.2222
p.P1633S	ACH-000124	Lymphoma	CCLE	DHDTGE	DEG_Kelch_Keap1_1	0.25
p.P1633S	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.25
p.P1639L	ACH-000239	Gastric Cancer	CCLE	DHDTGE	DEG_Kelch_Keap1_1	0.7582
p.P1650H	ACH-000774	Lung Cancer	CCLE	DHDTGE	DEG_Kelch_Keap1_1	0.0833
p.R1640W	ACH-000938	Leukemia	CCLE	DHDTGE	DEG_Kelch_Keap1_1	0.8634
p.R1640W	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.8634
p.R1629W	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.25
p.R1647W	CW-2	large_intestine	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.1667
p.P1628Q	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.1111
p.P1639Q	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.7035
p.V1645I	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	DHDTGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13402	Unconventional myosin-VIIa	DEG_Kelch_Keap1_1	1636:1641	DHDTGE	KEAP1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DHDTGE

Degron related mutations and impact score

Drug responses associated with MYO7A mutations

All proteins holding degron of DHDTGE