DegronMD - Q13415(ORC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E238Q	TCGA-C8-A12T	BRCA	TCGA	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5633
p.E238Q	DO5507	BRCA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5633
p.G243C	TCGA-GN-A263	SKCM	TCGA	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6489
p.G243C	DO37766	SKCM	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.6489
p.A233D	DO229028	LICA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.2778
p.P225T	DO232224	PBCA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0556
p.C253S	DO47012	RECA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation rewiring degron network	0.0556
p.N241D	SIDM01609	Endometrial Carcinoma	GDSC	KRLELGNLG	DEG_APCC_DBOX_1	235:243	Mutation altering degron motif	0.5821

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons