DegronMD

Uniprot ID: Q13415

Source protein: Origin recognition complex subunit 1

Source gene: ORC1

Class: DEG_APCC_DBOX_1

Location: 235:243

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8456

ASA_SCORE: 85.9444

COIL: 0.635

CONS_SCORE: 0.2296

DSS_SCORE: 0.7102

HELIX: 0.2388

FCONS_SCORE: 1.0936

RIG_SCORE: 0.6733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E238Q	TCGA-C8-A12T	BRCA	TCGA	KRLELGNLG	DEG_APCC_DBOX_1	0.5633
p.E238Q	DO5507	BRCA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	0.5633
p.G243C	TCGA-GN-A263	SKCM	TCGA	KRLELGNLG	DEG_APCC_DBOX_1	0.6489
p.G243C	DO37766	SKCM	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	0.6489
p.A233D	DO229028	LICA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	0.2778
p.P225T	DO232224	PBCA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	0.0556
p.C253S	DO47012	RECA	ICGC	KRLELGNLG	DEG_APCC_DBOX_1	0.0556
p.N241D	SIDM01609	Endometrial Carcinoma	GDSC	KRLELGNLG	DEG_APCC_DBOX_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13415	Origin recognition complex subunit 1	DEG_APCC_DBOX_1	235:243	KRLELGNLG	APC,CDC20,FZR1	0.8456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons