DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
KRLELGNLG
Uniprot ID:
Q13415
Source protein:
Origin recognition complex subunit 1
Source gene:
ORC1
Class:
DEG_APCC_DBOX_1
Location:
235:243
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8456
ASA_SCORE:
85.9444
COIL:
0.635
CONS_SCORE:
0.2296
DSS_SCORE:
0.7102
HELIX:
0.2388
FCONS_SCORE:
1.0936
RIG_SCORE:
0.6733
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G243C
TCGA-GN-A263
SKCM
TCGA
KRLELGNLG
DEG_APCC_DBOX_1
0.6489
p.G243C
DO37766
SKCM
ICGC
KRLELGNLG
DEG_APCC_DBOX_1
0.6489
p.N241D
SIDM01609
Endometrial Carcinoma
GDSC
KRLELGNLG
DEG_APCC_DBOX_1
0.5821
p.E238Q
TCGA-C8-A12T
BRCA
TCGA
KRLELGNLG
DEG_APCC_DBOX_1
0.5633
p.E238Q
DO5507
BRCA
ICGC
KRLELGNLG
DEG_APCC_DBOX_1
0.5633
p.A233D
DO229028
LICA
ICGC
KRLELGNLG
DEG_APCC_DBOX_1
0.2778
p.P225T
DO232224
PBCA
ICGC
KRLELGNLG
DEG_APCC_DBOX_1
0.0556
p.C253S
DO47012
RECA
ICGC
KRLELGNLG
DEG_APCC_DBOX_1
0.0556
Showing 1 to 8 of 8 entries
Previous
1
Next
Drug responses associated with ORC1 mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of KRLELGNLG
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q13415
Origin recognition complex subunit 1
DEG_APCC_DBOX_1
235:243
KRLELGNLG
APC,CDC20,FZR1
0.8456
More...
Showing 1 to 1 of 1 entries
Previous
1
Next