SNTA1
UniProt ID: Q13424
Entrez ID: 6640
Protein name: Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and i...
FUNCTION: Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
muscle contraction [GO:0006936]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuromuscular junction development [GO:0007528]; regulation of heart rate [GO:0002027]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of vasoconstriction by circulating...
muscle contraction [GO:0006936]; negative regulation of peptidyl-cysteine S-nitrosylation [GO:1902083]; neuromuscular junction development [GO:0007528]; regulation of heart rate [GO:0002027]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of vasoconstriction by circulating norepinephrine [GO:0003117]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; ventricular cardiac muscle cell action potential [GO:0086005]
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GO - Molecular function (MF):
actin binding [GO:0003779]; ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; nitric-oxide synthase binding [GO:0050998]; PDZ domain binding [GO:0030165]; sodium channel regulator activity [GO:0017080]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044...
actin binding [GO:0003779]; ATPase binding [GO:0051117]; calmodulin binding [GO:0005516]; nitric-oxide synthase binding [GO:0050998]; PDZ domain binding [GO:0030165]; sodium channel regulator activity [GO:0017080]; structural molecule activity [GO:0005198]; transmembrane transporter binding [GO:0044325]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; neuromuscular junction [GO:0031594]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; syntrophin complex [GO:0016013]...
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; neuromuscular junction [GO:0031594]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; synapse [GO:0045202]; syntrophin complex [GO:0016013]
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SNTA1
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Kaplan plot for SNTA1 in
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*NOTE: the Kaplan plots were collected from OncoLnc