DegronMD

Uniprot ID: Q13424

Source protein: Alpha-1-syntrophin

Source gene: SNTA1

Class: DEG_APCC_DBOX_1

Location: 8:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9226

ASA_SCORE: 47.9667

COIL: 0.2752

CONS_SCORE: 0.5097

DSS_SCORE: 0.4901

HELIX: 0.0121

FCONS_SCORE: 1.5118

RIG_SCORE: 0.7543

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G20S	DO220906	MELA	ICGC	PRTGLLELR	DEG_APCC_DBOX_1	0.2222
p.P8L	ACH-000923	Lymphoma	CCLE	PRTGLLELR	DEG_APCC_DBOX_1	0.6471
p.R9C	ACH-002510	Skin Cancer	CCLE	PRTGLLELR	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13424	Alpha-1-syntrophin	DEG_APCC_DBOX_1	8:16	PRTGLLELR	APC,CDC20,FZR1	0.9226	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons