DegronMD - Q13464(ROCK1)

FUNCTION: Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:10436159, PubMed:10652353, PubMed:11018042, PubMed:11283607, PubMed:17158456, PubMed:18573880, PubMed:19131646, PubMed:8617235, PubMed:9722579, PubMed:23093407, PubMed:23355470). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing (PubMed:18694941). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (PubMed:19036714). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (By similarity). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation (PubMed:19181962). Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (PubMed:21072057). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Promotes keratinocyte terminal differentiation (PubMed:19997641). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (By similarity). {ECO:0000250|UniProtKB:P70335, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:10652353, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:11283607, ECO:0000269|PubMed:17158456, ECO:0000269|PubMed:18573880, ECO:0000269|PubMed:18694941, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19131646, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:19997641, ECO:0000269|PubMed:21072057, ECO:0000269|PubMed:23093407, ECO:0000269|PubMed:23355470, ECO:0000269|PubMed:8617235, ECO:0000269|PubMed:9722579}. View more >>

GO - Biological processes (BP): actin cytoskeleton organization [GO:0030036]; actomyosin structure organization [GO:0031032]; aortic valve morphogenesis [GO:0003180]; apical constriction [GO:0003383]; apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; blood vessel diameter maintenance [GO:0097746]; cortical actin cytoskeleton organization [GO:0030866]; embryonic morphogenesis [GO:0048598]; epithelial to mesenchymal transition [GO:0001837]; glomerular visceral epithelial cell migration [GO:0090521]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; mitotic cytokinesis [GO:0000281]; mRNA destabilization [GO:0061157]; myoblast migration [GO:0051451]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of phosphorylation [GO:0042326]; negative regulation of protein binding [GO:0032091]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of dephosphorylation [GO:0035306]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatase activity [GO:0010922]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of amyloid-beta formation [GO:1902003]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of autophagy [GO:0010506]; regulation of cell adhesion [GO:0030155]; regulation of cell junction assembly [GO:1901888]; regulation of cell migration [GO:0030334]; regulation of cell motility [GO:2000145]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of neuron differentiation [GO:0045664]; regulation of stress fiber assembly [GO:0051492]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1100C	TCGA-21-1077	LUSC	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation blocking phosphorylation signal	0.7222
p.S1100C	DO26725	LUSC	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation blocking phosphorylation signal	0.7222
p.V1103I	TCGA-AP-A1DK	UCEC	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1944
p.V1103I	DO42033	UCEC	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.1944
p.P1107A	TCGA-CG-4301	STAD	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0833
p.P1107A	DO38879	STAD	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0833
p.S1100F	TCGA-DU-6407	LGG	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation blocking phosphorylation signal	0.7222
p.S1100F	DO22295	LGG	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation blocking phosphorylation signal	0.7222
p.A1081D	TCGA-EI-6507	READ	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0833
p.A1081D	DO36675	READ	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.0833
p.L1095S	TCGA-KK-A59V	PRAD	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.6556
p.L1095S	DO51346	PRAD	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.6556
p.R1091S	DO229029	LICA	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.7427
p.A1092D	DO229031	LICA	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.6682
p.K1083I	SIDM00120	Prostate Carcinoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation substituting flanking lysine	0.25
p.K1083I	ACH-000979	Prostate Cancer	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation substituting flanking lysine	0.25
p.K1083I	DU-145	prostate	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation substituting flanking lysine	0.25
p.L1090S	SIDM01045	Endometrial Carcinoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.6556
p.L1090S	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.6556
p.L1090S	EN	endometrium	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.6556
p.S1098L	SIDM00837	Colorectal Carcinoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.7667
p.S1098L	ACH-000958	Colon/Colorectal Cancer	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.7667
p.S1098L	SW48	large intestine	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.7667
p.D1086H	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.2222
p.D1086H	ACH-001498	Lymphoma	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.2222
p.D1086H	Farage	haematopoietic and lymphoid tissue	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation rewiring degron network	0.2222
p.R1091C	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.8301
p.R1091C	ACH-000942	Leukemia	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	1090:1098	Mutation altering degron motif	0.8301

Kaplan plot for ROCK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ROCK1

UniProt ID: Q13464

Entrez ID: 6093

Protein name: Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ROCK1 in