DegronMD

Uniprot ID: Q13464

Source protein: Rho-associated protein kinase 1

Source gene: ROCK1

Class: DEG_APCC_DBOX_1

Location: 1090:1098

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6431

ASA_SCORE: 101.8556

COIL: 0.2069

CONS_SCORE: 0.4065

DSS_SCORE: 0.3754

HELIX: 0.7974

FCONS_SCORE: 0.9751

RIG_SCORE: 0.7686

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1100C	TCGA-21-1077	LUSC	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	0.7222
p.S1100C	DO26725	LUSC	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.7222
p.V1103I	TCGA-AP-A1DK	UCEC	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	0.1944
p.V1103I	DO42033	UCEC	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.1944
p.P1107A	TCGA-CG-4301	STAD	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	0.0833
p.P1107A	DO38879	STAD	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.0833
p.S1100F	TCGA-DU-6407	LGG	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	0.7222
p.S1100F	DO22295	LGG	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.7222
p.A1081D	TCGA-EI-6507	READ	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	0.0833
p.A1081D	DO36675	READ	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.0833
p.L1095S	TCGA-KK-A59V	PRAD	TCGA	LRAKLLDLS	DEG_APCC_DBOX_1	0.6556
p.L1095S	DO51346	PRAD	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.6556
p.R1091S	DO229029	LICA	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.7427
p.A1092D	DO229031	LICA	ICGC	LRAKLLDLS	DEG_APCC_DBOX_1	0.6682
p.K1083I	SIDM00120	Prostate Carcinoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	0.25
p.K1083I	ACH-000979	Prostate Cancer	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	0.25
p.K1083I	DU-145	prostate	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	0.25
p.L1090S	SIDM01045	Endometrial Carcinoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	0.6556
p.L1090S	ACH-000978	Endometrial/Uterine Cancer	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	0.6556
p.L1090S	EN	endometrium	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	0.6556
p.S1098L	SIDM00837	Colorectal Carcinoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	0.7667
p.S1098L	ACH-000958	Colon/Colorectal Cancer	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	0.7667
p.S1098L	SW48	large_intestine	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	0.7667
p.D1086H	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	0.2222
p.D1086H	ACH-001498	Lymphoma	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	0.2222
p.D1086H	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LRAKLLDLS	DEG_APCC_DBOX_1	0.2222
p.R1091C	SIDM01618	B-Lymphoblastic Leukemia	GDSC	LRAKLLDLS	DEG_APCC_DBOX_1	0.8301
p.R1091C	ACH-000942	Leukemia	CCLE	LRAKLLDLS	DEG_APCC_DBOX_1	0.8301

Drug responses associated with ROCK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.P1321L (No)	GDSC	GSK269962A	8.4102
SIDM01045	UCEC\|endometrium	p.K1307fs*3 (No)	GDSC	GSK429286A	101.1162
SIDM01045	UCEC\|endometrium	p.K1307fs*3 (No)	GDSC	GSK269962A	6.1907
SIDM01045	UCEC\|endometrium	p.W122fs*25 (No)	GDSC	GSK429286A	101.1162
SIDM01045	UCEC\|endometrium	p.W122fs*25 (No)	GDSC	GSK269962A	6.1907
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.K1307fs*3 (No)	GDSC	GSK269962A	9.432
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.K1307fs*3 (No)	GDSC	GSK429286A	204.9826
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.K1307fs*3 (No)	GDSC	GSK269962A	7.2023
SIDM01051	UNCLASSIFIED\|ovary	p.K1307fs*3 (No)	GDSC	GSK429286A	228.8899
SIDM01051	UNCLASSIFIED\|ovary	p.K1307fs*3 (No)	GDSC	GSK269962A	0.2038
SIDM00145	ALL\|lymphoblastic_leukemia	p.I63L (No)	GDSC	GSK269962A	7.778
SIDM00145	ALL\|lymphoblastic_leukemia	p.I63L (No)	GDSC	GSK429286A	21.024
SIDM00145	ALL\|lymphoblastic_leukemia	p.I63L (No)	GDSC	GSK269962A	1.5315
SIDM00121	ALL\|lymphoblastic_leukemia	p.R403H (No)	GDSC	GSK269962A	3.8849
SIDM00121	ALL\|lymphoblastic_leukemia	p.R403H (No)	GDSC	GSK429286A	42.4901
SIDM00121	ALL\|lymphoblastic_leukemia	p.R403H (No)	GDSC	GSK269962A	1.1715
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.N64S (No)	GDSC	GSK429286A	233.1526
SIDM00494	LUAD\|lung_NSCLC_adenocarcinoma	p.N64S (No)	GDSC	GSK269962A	11.0512
SIDM00683	PRAD\|prostate	p.V229A (No)	GDSC	GSK269962A	40.4901
SIDM00683	PRAD\|prostate	p.V229A (No)	GDSC	GSK429286A	101.2016
SIDM00683	PRAD\|prostate	p.V229A (No)	GDSC	GSK269962A	14.9813
SIDM00859	DLBC\|B_cell_lymphoma	p.D1086H (Yes)	GDSC	GSK269962A	7.8772
SIDM00859	DLBC\|B_cell_lymphoma	p.D1086H (Yes)	GDSC	GSK429286A	26.123
SIDM00859	DLBC\|B_cell_lymphoma	p.D1086H (Yes)	GDSC	GSK269962A	20.4979
SIDM00214	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK429286A	114.299
SIDM00214	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK269962A	0.9948
SIDM00214	COREAD\|large_intestine	p.I1150fs*21 (No)	GDSC	GSK429286A	114.299
SIDM00214	COREAD\|large_intestine	p.I1150fs*21 (No)	GDSC	GSK269962A	0.9948
SIDM00781	COREAD\|large_intestine	p.T480fs*5 (No)	GDSC	GSK429286A	195.0132
SIDM00781	COREAD\|large_intestine	p.T480fs*5 (No)	GDSC	GSK269962A	11.8983
SIDM00334	UCEC\|endometrium	p.K1307fs*3 (No)	GDSC	GSK429286A	276.0577
SIDM00334	UCEC\|endometrium	p.K1307fs*3 (No)	GDSC	GSK269962A	4.1441
SIDM00818	KIRC\|kidney	p.A386P (No)	GDSC	GSK429286A	6.0078
SIDM00818	KIRC\|kidney	p.A386P (No)	GDSC	GSK269962A	0.1232
SIDM00250	ESCA\|oesophagus	p.L962P (No)	GDSC	GSK429286A	137.3148
SIDM00250	ESCA\|oesophagus	p.L962P (No)	GDSC	GSK269962A	6.4331
SIDM00537	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK429286A	191.6123
SIDM00537	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK269962A	23.7251
SIDM01174	CESC\|cervix	p.E915Q (No)	GDSC	GSK429286A	410.2907
SIDM01174	CESC\|cervix	p.E915Q (No)	GDSC	GSK269962A	7.2465
SIDM00565	HNSC\|head_and_neck	p.L371S (No)	GDSC	GSK429286A	122.0573
SIDM00565	HNSC\|head_and_neck	p.L371S (No)	GDSC	GSK269962A	19.5745
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.A180S (No)	GDSC	GSK269962A	0.7006
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.A180S (No)	GDSC	GSK429286A	23.0775
SIDM00261	UNCLASSIFIED\|ewings_sarcoma	p.A180S (No)	GDSC	GSK269962A	2.2647
SIDM00443	DLBC\|B_cell_lymphoma	p.M223I (No)	GDSC	GSK269962A	10.2582
SIDM00443	DLBC\|B_cell_lymphoma	p.M223I (No)	GDSC	GSK429286A	34.9535
SIDM00443	DLBC\|B_cell_lymphoma	p.M223I (No)	GDSC	GSK269962A	22.9877
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R1019G (No)	GDSC	GSK269962A	1.6986
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R1019G (No)	GDSC	GSK429286A	57.693
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.R1019G (No)	GDSC	GSK269962A	8.7583
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R403H (No)	GDSC	GSK269962A	13.1614
SIDM01090	COREAD\|large_intestine	p.V735I (No)	GDSC	GSK269962A	3.5412
SIDM01090	COREAD\|large_intestine	p.V735I (No)	GDSC	GSK429286A	124.1141
SIDM01090	COREAD\|large_intestine	p.V735I (No)	GDSC	GSK269962A	35.383
SIDM01090	COREAD\|large_intestine	p.E717K (No)	GDSC	GSK269962A	3.5412
SIDM01090	COREAD\|large_intestine	p.E717K (No)	GDSC	GSK429286A	124.1141
SIDM01090	COREAD\|large_intestine	p.E717K (No)	GDSC	GSK269962A	35.383
SIDM01090	COREAD\|large_intestine	p.D447N (No)	GDSC	GSK269962A	3.5412
SIDM01090	COREAD\|large_intestine	p.D447N (No)	GDSC	GSK429286A	124.1141
SIDM01090	COREAD\|large_intestine	p.D447N (No)	GDSC	GSK269962A	35.383
SIDM01043	UNCLASSIFIED\|endometrium	p.E915* (No)	GDSC	GSK429286A	31.5075
SIDM01043	UNCLASSIFIED\|endometrium	p.E915* (No)	GDSC	GSK269962A	8.9434
SIDM00151	OV\|ovary	p.W1308fs*11 (No)	GDSC	GSK269962A	12.9719
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.N496D (No)	GDSC	GSK269962A	16.9894
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.N496D (No)	GDSC	GSK429286A	145.8941
SIDM00482	LCML\|chronic_myeloid_leukaemia	p.N496D (No)	GDSC	GSK269962A	3.9375
SIDM00858	UNCLASSIFIED\|osteosarcoma	p.E980K (No)	GDSC	GSK429286A	130.1325
SIDM00858	UNCLASSIFIED\|osteosarcoma	p.E980K (No)	GDSC	GSK269962A	2.05
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.V1285I (No)	GDSC	GSK269962A	0.4558
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.V1285L (No)	GDSC	GSK269962A	37.8317
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.V1285L (No)	GDSC	GSK429286A	360.878
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.P1239T (No)	GDSC	GSK269962A	37.8317
SIDM01117	SCLC\|lung_small_cell_carcinoma	p.P1239T (No)	GDSC	GSK429286A	360.878
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.L755V (No)	GDSC	GSK269962A	34.451
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.L755V (No)	GDSC	GSK429286A	164.9945
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.L755V (No)	GDSC	GSK269962A	19.6432
SIDM01045	UCEC\|endometrium	p.L1090S (Yes)	GDSC	GSK429286A	101.1162
SIDM01045	UCEC\|endometrium	p.L1090S (Yes)	GDSC	GSK269962A	6.1907
SIDM00056	THCA\|thyroid	p.Q1001E (No)	GDSC	GSK269962A	3.9677
SIDM00056	THCA\|thyroid	p.Q1001E (No)	GDSC	GSK429286A	203.95
SIDM00056	THCA\|thyroid	p.Q1001E (No)	GDSC	GSK269962A	2.7336
SIDM00495	DLBC\|B_cell_lymphoma	p.M743I (No)	GDSC	GSK269962A	2.9716
SIDM00495	DLBC\|B_cell_lymphoma	p.M743I (No)	GDSC	GSK429286A	16.5204
SIDM00495	DLBC\|B_cell_lymphoma	p.M743I (No)	GDSC	GSK269962A	2.455
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q91E (No)	GDSC	GSK269962A	21.7997
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q91E (No)	GDSC	GSK429286A	76.8914
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.Q91E (No)	GDSC	GSK269962A	10.8935
SIDM00489	HNSC\|head_and_neck	p.D42Y (No)	GDSC	GSK429286A	93.6704
SIDM00489	HNSC\|head_and_neck	p.D42Y (No)	GDSC	GSK269962A	7.8956
SIDM01027	ESCA\|oesophagus	p.D1014fs*14 (No)	GDSC	GSK429286A	44.8001
SIDM01027	ESCA\|oesophagus	p.D1014fs*14 (No)	GDSC	GSK269962A	11.4415
SIDM00282	COREAD\|large_intestine	p.D1014V (No)	GDSC	GSK269962A	43.0734
SIDM00282	COREAD\|large_intestine	p.D1014V (No)	GDSC	GSK429286A	150.6915
SIDM00282	COREAD\|large_intestine	p.D1014V (No)	GDSC	GSK269962A	13.4125
SIDM00282	COREAD\|large_intestine	p.M489T (No)	GDSC	GSK269962A	43.0734
SIDM00282	COREAD\|large_intestine	p.M489T (No)	GDSC	GSK429286A	150.6915
SIDM00282	COREAD\|large_intestine	p.M489T (No)	GDSC	GSK269962A	13.4125
SIDM00282	COREAD\|large_intestine	p.C231Y (No)	GDSC	GSK269962A	43.0734
SIDM00282	COREAD\|large_intestine	p.C231Y (No)	GDSC	GSK429286A	150.6915
SIDM00282	COREAD\|large_intestine	p.C231Y (No)	GDSC	GSK269962A	13.4125
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.L881I (No)	GDSC	GSK269962A	17.2859
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.L881I (No)	GDSC	GSK429286A	120.9496
SIDM00205	UNCLASSIFIED\|ewings_sarcoma	p.L881I (No)	GDSC	GSK269962A	52.6003
SIDM00685	GBM\|glioma	p.E942G (No)	GDSC	GSK429286A	134.8496
SIDM00685	GBM\|glioma	p.E942G (No)	GDSC	GSK269962A	6.3912
SIDM00637	DLBC\|B_cell_lymphoma	p.Q838E (No)	GDSC	GSK269962A	3.0107
SIDM00637	DLBC\|B_cell_lymphoma	p.Q838E (No)	GDSC	GSK429286A	51.1868
SIDM00637	DLBC\|B_cell_lymphoma	p.Q838E (No)	GDSC	GSK269962A	1.5991
SIDM00363	LAML\|acute_myeloid_leukaemia	p.T949I (No)	GDSC	GSK269962A	16.9159
SIDM00363	LAML\|acute_myeloid_leukaemia	p.T949I (No)	GDSC	GSK429286A	68.8145
SIDM00363	LAML\|acute_myeloid_leukaemia	p.T949I (No)	GDSC	GSK269962A	0.0399
SIDM00150	COREAD\|large_intestine	p.A655T (No)	GDSC	GSK269962A	4.1902
SIDM00150	COREAD\|large_intestine	p.A655T (No)	GDSC	GSK429286A	409.3924
SIDM00150	COREAD\|large_intestine	p.A655T (No)	GDSC	GSK269962A	74.2967
SIDM00216	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK429286A	173.174
SIDM00216	COREAD\|large_intestine	p.M14fs*27 (No)	GDSC	GSK429286A	173.174
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.E670D (No)	GDSC	GSK269962A	14.4577
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.E670D (No)	GDSC	GSK429286A	147.8384
SIDM00297	LUAD\|lung_NSCLC_adenocarcinoma	p.E670D (No)	GDSC	GSK269962A	8.0305
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.S482C (No)	GDSC	GSK269962A	70.3552
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.S482C (No)	GDSC	GSK429286A	409.6348
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.S482C (No)	GDSC	GSK269962A	93.7728
SIDM00150	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK269962A	4.1902
SIDM00150	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK429286A	409.3924
SIDM00150	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK269962A	74.2967
SIDM00820	KIRC\|kidney	p.K1005fs*5 (No)	GDSC	GSK429286A	315.4408
SIDM00820	KIRC\|kidney	p.K1005fs*5 (No)	GDSC	GSK269962A	48.3051
SIDM00789	COREAD\|large_intestine	p.R58S (No)	GDSC	GSK429286A	258.0693
SIDM00789	COREAD\|large_intestine	p.R58S (No)	GDSC	GSK269962A	23.5648
SIDM00534	COREAD\|large_intestine	p.R1262* (No)	GDSC	GSK429286A	93.4991
SIDM00534	COREAD\|large_intestine	p.R1262* (No)	GDSC	GSK269962A	2.1446
SIDM00534	COREAD\|large_intestine	p.R1012Q (No)	GDSC	GSK429286A	93.4991
SIDM00534	COREAD\|large_intestine	p.R1012Q (No)	GDSC	GSK269962A	2.1446
SIDM00534	COREAD\|large_intestine	p.R630Q (No)	GDSC	GSK429286A	93.4991
SIDM00534	COREAD\|large_intestine	p.R630Q (No)	GDSC	GSK269962A	2.1446
SIDM00534	COREAD\|large_intestine	p.K50T (No)	GDSC	GSK429286A	93.4991
SIDM00534	COREAD\|large_intestine	p.K50T (No)	GDSC	GSK269962A	2.1446
SIDM00680	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK429286A	331.839
SIDM00680	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK269962A	5.4619
SIDM00487	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK429286A	281.9974
SIDM00487	COREAD\|large_intestine	p.K1307fs*3 (No)	GDSC	GSK269962A	30.1006
SIDM00487	COREAD\|large_intestine	p.E789K (No)	GDSC	GSK429286A	281.9974
SIDM00487	COREAD\|large_intestine	p.E789K (No)	GDSC	GSK269962A	30.1006
SIDM00487	COREAD\|large_intestine	p.K452E (No)	GDSC	GSK429286A	281.9974
SIDM00487	COREAD\|large_intestine	p.K452E (No)	GDSC	GSK269962A	30.1006
SIDM00282	COREAD\|large_intestine	p.W122fs*25 (No)	GDSC	GSK269962A	43.0734
SIDM00282	COREAD\|large_intestine	p.W122fs*25 (No)	GDSC	GSK429286A	150.6915
SIDM00282	COREAD\|large_intestine	p.W122fs*25 (No)	GDSC	GSK269962A	13.4125
SIDM00217	COREAD\|large_intestine	p.T431fs*4 (No)	GDSC	GSK429286A	167.3896
SIDM00217	COREAD\|large_intestine	p.T431fs*4 (No)	GDSC	GSK269962A	26.5742
SIDM00545	SKCM\|melanoma	p.Q703H (No)	GDSC	GSK429286A	441.338
SIDM00545	SKCM\|melanoma	p.Q703H (No)	GDSC	GSK269962A	32.1229
SIDM00120	PRAD\|prostate	p.K1083I (Yes)	GDSC	GSK429286A	242.1882
SIDM00120	PRAD\|prostate	p.K1083I (Yes)	GDSC	GSK269962A	3.2789
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.E919G (No)	GDSC	GSK429286A	495.1392
SIDM00930	UNCLASSIFIED\|osteosarcoma	p.E919G (No)	GDSC	GSK269962A	2.0441
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Q249E (No)	GDSC	GSK429286A	136.1869
SIDM01103	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Q249E (No)	GDSC	GSK269962A	19.5044
SIDM00980	STAD\|stomach	p.K1307fs*3 (No)	GDSC	GSK429286A	214.6125
SIDM00980	STAD\|stomach	p.K1307fs*3 (No)	GDSC	GSK269962A	7.8058
SIDM00980	STAD\|stomach	p.I952fs*2 (No)	GDSC	GSK429286A	214.6125
SIDM00980	STAD\|stomach	p.I952fs*2 (No)	GDSC	GSK269962A	7.8058
SIDM00580	LAML\|acute_myeloid_leukaemia	p.R147C (No)	GDSC	GSK269962A	7.6645
SIDM00580	LAML\|acute_myeloid_leukaemia	p.R147C (No)	GDSC	GSK429286A	58.2724
SIDM00580	LAML\|acute_myeloid_leukaemia	p.R147C (No)	GDSC	GSK269962A	10.0353
SIDM00481	OV\|ovary	p.T9fs*4 (No)	GDSC	GSK429286A	455.8031
SIDM00481	OV\|ovary	p.T9fs*4 (No)	GDSC	GSK269962A	78.2129
SIDM01040	OV\|ovary	p.S108N (No)	GDSC	GSK429286A	480.8921
SIDM01040	OV\|ovary	p.S108N (No)	GDSC	GSK269962A	14.8099
SIDM00659	GBM\|glioma	p.Q492* (No)	GDSC	GSK429286A	61.6716
SIDM00659	GBM\|glioma	p.Q492* (No)	GDSC	GSK269962A	7.3087
SIDM00837	COREAD\|large_intestine	p.S1098L (Yes)	GDSC	GSK429286A	51.0314
SIDM00837	COREAD\|large_intestine	p.S1098L (Yes)	GDSC	GSK269962A	0.8309
SIDM00118	COREAD\|large_intestine	p.K666N (No)	GDSC	GSK269962A	11.5528
SIDM00118	COREAD\|large_intestine	p.K666N (No)	GDSC	GSK429286A	225.5816
SIDM00118	COREAD\|large_intestine	p.K666N (No)	GDSC	GSK269962A	56.652
SIDM00118	COREAD\|large_intestine	p.R115I (No)	GDSC	GSK269962A	11.5528
SIDM00118	COREAD\|large_intestine	p.R115I (No)	GDSC	GSK429286A	225.5816
SIDM00118	COREAD\|large_intestine	p.R115I (No)	GDSC	GSK269962A	56.652

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRAKLLDLS

Degron related mutations and impact score

Drug responses associated with ROCK1 mutations

All proteins holding degron of LRAKLLDLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13464	Rho-associated protein kinase 1	DEG_APCC_DBOX_1	1090:1098	LRAKLLDLS	APC,CDC20,FZR1	0.6431	More...